Solid pyrolysis synthesis of excitation-independent emission carbon dots and its application to isoniazid detection
- 32 Downloads
In this paper, a novel fluorescence carbon dots (FCDs) were proposed to use folic acid as the sole reactant via the pyrolytic way. The gotten FCDs were uniform in size distribution and had an excitation-independent emission feature, and their fluorescence quantum yield was 39.09%. Without additional modification, the acquired FCDs could be used to detect isoniazid by the fluorescence quenching pattern. The reaction mechanism was the synergy of the internal filtration effect and the static quenching effect. The linear range of the detection of isoniazid was 4.0–140 μM, and the detection limit was 1.15 μM. Therefore, the method for the determination of isoniazid was put forward. The method was applied to the detection of isoniazid in isoniazid tablets with the recovery rates of 98.12 to 102.67%, and the results were satisfactory.
KeywordsCarbon dots Fluorescence quenching Isoniazid analysis Inner filter effect Static quenching effect Drug testing applications
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Wang EK, Zhou WH (1996) Determination of isoniazid and hydrazine by capillary electrophoresis with amperometric detection at a Pt-particle modified carbon fiber microelectrode. Chin J Chem 14:131–137Google Scholar
- Wu B, Wang Z, Xue Z, Zhou X, Du J, Liu X, Lu X (2012b) A novel molecularly imprinted electrochemiluminescence sensor for isoniazid detection. Analyst 137:3644–3652Google Scholar
- Wu D, Zhang F, Liang H, Feng X (2012a) Nanocomposites and macroscopic materials: assembly of chemically modified graphene sheets. Chem Soc Rev 41:6160–6177Google Scholar
- Zhu S, Song Y, Zhao X, Shao J, Zhang J, Yang B (2015) The photoluminescence mechanism in carbon dots (graphene quantum dots, carbon nanodots, and polymer dots): current state and future perspective. Nano Rev 8:355–381Google Scholar