Solid pyrolysis synthesis of excitation-independent emission carbon dots and its application to isoniazid detection

  • Ju Qin
  • Limei Zhang
  • Rui YangEmail author
Research Paper


In this paper, a novel fluorescence carbon dots (FCDs) were proposed to use folic acid as the sole reactant via the pyrolytic way. The gotten FCDs were uniform in size distribution and had an excitation-independent emission feature, and their fluorescence quantum yield was 39.09%. Without additional modification, the acquired FCDs could be used to detect isoniazid by the fluorescence quenching pattern. The reaction mechanism was the synergy of the internal filtration effect and the static quenching effect. The linear range of the detection of isoniazid was 4.0–140 μM, and the detection limit was 1.15 μM. Therefore, the method for the determination of isoniazid was put forward. The method was applied to the detection of isoniazid in isoniazid tablets with the recovery rates of 98.12 to 102.67%, and the results were satisfactory.


Carbon dots Fluorescence quenching Isoniazid analysis Inner filter effect Static quenching effect Drug testing applications 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, School of Chemistry and Chemical EngineeringSouthwest UniversityChongqingChina

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