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Shape controlled quantum dot (QD)-decorated-mesoporous SiO2 (m-SiO2/QD) hollow particles for photodynamic therapy

  • Jingyu Si
  • Jianfeng Zhang
  • Jinyu Duan
  • Huajian Xu
  • Qunling Fang
Research Paper
  • 30 Downloads

Abstract

This work reported a novel kind of CdTe quantum dot (QD) decorated mesoporous SiO2 (m-SiO2/QD) hybrid hollow nanoparticles for carrying photodynamic therapy (PDT) reagent. Both rod-like and spherical nanoparticles were prepared by using different shaped templates. Due to the porous shell and hollow interior, the hybrid m-SiO2/QD hollow nanorod with 360 nm long and 120 nm in diameter was selected for carrying zinc(II) phthalocyanine (ZnPc) photosensitizing molecules (61 mg/g) since the generated reactive 1O2 could be easily delivered out of the hollow particles through the porous shell (BET area 251 cm2/g). It was found that the m-SiO2/QD-ZnPc hollow nanorods exhibited a good PDT activity and showed effective photocytotoxicity for the cancer cells. Because of the porous nature, fluorescence characteristic, and excellent storage ability, the m-SiO2/QD hybrid hollow particles possessed broad potential in the fluorescent labeled PDT.

Graphic abstract

m-SiO2/QD hybrid hollow particles with different morphologies could be successfully synthesized by using the templating method and they could be used as carriers for photodynamic therapy reagents.

Keywords

Hollow Porous Fluorescence SiO2 Photodynamic therapy (PDT) 

Notes

Funding information

Financial supports were from the National Natural Science Foundation of China (Grant Nos. 21205026), Key Project of Natural Science Research of Universities in Anhui Province (KJ2018A0550), and the Fundamental Research Funds for the Central Universities.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

11051_2018_4415_MOESM1_ESM.docx (2.6 mb)
ESM 1 (DOCX 2703 kb)

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Chemistry and Materials EngineeringHefei UniversityHefeiPeople’s Republic of China
  2. 2.School of Food and Biological EngineeringHefei University of TechnologyHefeiPeople’s Republic of China

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