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Amphiphilic graft polymer with reduction breakable main chain prepared via click polymerization and grafting onto

  • Xiaojin Zhang
  • Yu Dai
Research Paper

Abstract

Amphiphilic graft polymer PSS-g-Pal/PEG with reduction breakable main chain was synthesized via click polymerization of dialkynyl (containing disulfide bond) and diazide (containing pendant diol) and one-pot grafting onto of hydrophobic palmitate (Pal) and hydrophilic methoxy poly(ethylene glycol) (PEG). PSS-g-Pal/PEG is able to form polymeric micelles by self-assembly in water via dialysis. Polymeric micelles are nano-sized spheres and the particle size is approximately 70 nm. Of note, polymeric micelles are reduction-responsive owing to the disulfide bonds in main chain of PSS-g-Pal/PEG. Therefore, polymeric micelles prepared from amphiphilic graft polymer PSS-g-Pal/PEG are able to fast release the drugs in the presence of the reducing agents such as DL-dithiothreitol (DTT).

Keywords

Amphiphilic graft polymer Reduction-responsive Click polymerization Grafting onto Micelles Drug delivery applications 

Notes

Funding

This work was financially supported by the National Natural Science Foundation of China (Nos. 51703209 and 21603196), the Natural Science Foundation of Hubei Province (No. 2017CFB217), and the Fundamental Research Funds for the Central Universities, China University of Geosciences (Wuhan) (Nos. CUG170601 and CUGL170406).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  1. 1.Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and ChemistryChina University of GeosciencesWuhanPeople’s Republic of China

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