Perspectives on the design of safer nanomaterials and manufacturing processes
- 447 Downloads
A concerted effort is being made to insert Prevention through Design principles into discussions of sustainability, occupational safety and health, and green chemistry related to nanotechnology. Prevention through Design is a set of principles, which includes solutions to design out potential hazards in nanomanufacturing including the design of nanomaterials, and strategies to eliminate exposures and minimize risks that may be related to the manufacturing processes and equipment at various stages of the lifecycle of an engineered nanomaterial.
KeywordsNanomaterial Prevention through design Responsible development Environmental and health effects
The authors express their gratitude to all of the participants at the Safe Nano Design conference.
The findings and conclusions in this report are those of the author(s) and do not necessarily represent the views of the National Institute for Occupational Safety and Health.
- AIHA (2008) Demonstrating the business value of industrial hygieneGoogle Scholar
- ANSI A, ASSE (2012) Z10-2012 occupational health & safety management systems. American Society of Safety Engineers, Park RidgeGoogle Scholar
- Baisch BL, Corson NM, Wade-Mercer P, Gelein R, Kennell AJ, Oberdörster G, Elder A (2014) Equivalent titanium dioxide nanoparticle deposition by intratracheal instillation and whole body inhalation: the effect of dose rate on acute respiratory tract inflammation. Part Fibre Toxicol 11(1):5CrossRefGoogle Scholar
- Brouwer DH (2012) Control banding approaches for nanomaterials. Ann Occup Hyg 56(5):506–514Google Scholar
- Dahm MM, Yencken MS, Schubauer-Berigan MK (2011) Exposure control strategies in the carbonaceous nanomaterial industry. J Occup Environ Med 53(6S):S68–S73Google Scholar
- Environmental Defense Fund, Dupont (2007) Nano risk framework. Environmental Defense, New YorkGoogle Scholar
- Hubbs A, Mercer R, Coad J, Battelli L, Willard P, Sriram K, Wolfarth M, Castranova V, Porter D (2009) Persistent pulmonary inflammation, airway mucous metaplasia and migration of multiwalled carbon nanotubes from the lung after subchronic exposure. Toxicologist 108(1):457Google Scholar
- ISO (2004) 14000 environmental management. International Standards Organization, GenevaGoogle Scholar
- ISO (2005) Iso/tc 229 nanotechnologies. I. O. f. S. T. Committee (ed) GenevaGoogle Scholar
- ISO (2008) 9001 quality management systems. International Standards Organization, GenevaGoogle Scholar
- ISO (2012) Standard iso/tr 13329:2012 nanomaterials—preparation of material safety data sheet. International Standards Organization, GenevaGoogle Scholar
- Johnson D, Kennedy AJ, Steevens JA, Methner MM (2009) Enhanced occupational exposure to nanomaterials when mixed in environmentally-relevant matrices. Toxicologist 108(1):460Google Scholar
- Kim SC, Chen DR, Qi C, Gelein RM, Finkelstein JN, Elder A, Bentley K, Oberdörster G, Pui DYH (2010) A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. Nanotoxicology 4(1):42–51. doi: 10.3109/17435390903374019
- Kuempel ED (2011) Carbon nanotube risk assessment: implications for exposure and medical monitoring. J Occup Environ Med 53:S91–S97. doi: 10.1097/JOM.0b013e31821b1f3f. Available from http://journals.lww.com/joem/Fulltext/2011/06001/Carbon_Nanotube_Risk_Assessment__Implications_for.21.aspx
- Leith D, Miller-Lionberg D, Casuccio G, Lersch T, Lentz H, Marchese A, Volckens J (2013) Development of a transfer function for a personal, thermophoretic nanoparticle sampler. Aerosol Sci Technol 48(1):81–89. doi: 10.1080/02786826.2013.861593. Available from http://dx.doi.org/10.1080/02786826.2013.861593. Accessed 09 Oct 2014
- Li N, Xia T, Nel AE (2008) The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles. Free Radic Biol Med 44(9):1689–1699. doi: 10.1016/j.freeradbiomed.2008.01.028. Available from http://www.sciencedirect.com/science/article/pii/S0891584908000713.
- Mandrell D, Truong L, Jephson C, Sarker MR, Moore A, Lang C, Simonich MT, Tanguay RL (2012) Automated zebrafish chorion removal and single embryo placement: optimizing throughput of zebrafish developmental toxicity screens. J Lab Autom 17(1):66–74. Available from http://jla.sagepub.com/content/17/1/66.abstract. doi: 10.1177/2211068211432197. Available from http://jla.sagepub.com/content/17/1/66.abstract.
- NIOSH (2009) Approaches to safe nanotechnology: managing the health and safety concerns associated with engineered nanomaterials. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (ed) CincinnatiGoogle Scholar
- NIOSH (2010) Prevention through design: plan for the national initiative. HHS Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, CincinnatiGoogle Scholar
- NIOSH (2011) Current intelligence bulletin 63: Occupational exposure to titanium dioxide. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (ed) CincinnatiGoogle Scholar
- NIOSH (2013) Current intelligence bulletin 65: Occupational exposure to carbon nanotubes and nanofibers. U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health (ed) CincinnatiGoogle Scholar
- Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16(6–7):437–445. doi: 10.1080/08958370490439597. Available from http://informahealthcare.com/doi/abs/10.1080/08958370490439597.
- OSHA (2012) Hazard communication. O. S. a. H. Adminstration (ed) [Federal Register Volume 77, Number 58 (Monday, March 26, 2012)Google Scholar
- Peterson J (1973) Principles for controlling the occupational environment. The industrial environment—its evaluation and control pp 74–117Google Scholar
- Porter DW, Hubbs AF, Mercer RR, Wu N, Wolfarth MG, Sriram K, Leonard S, Battelli L, Schwegler-Berry D, Friend S, Andrew M, Chen BT, Tsuruoka S, Endo M, Castranova V (2010) Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269(2–3):136–147. Available from http://www.sciencedirect.com/science/article/pii/S0300483X09005216. doi: 10.1016/j.tox.2009.10.017
- Roussel C, Connor T (2014) Chemotherapy: current and emerging issues in safe handling of antineoplastic and other hazardous drugs. Oncol Pharm 7(3):8–11. Available from http://theoncologypharmacist.com/top-issues/2014-issues/august-2014-vol-7-no-3
- Sager TM, Wolfarth MW, Andrew M, Hubbs A, Friend S, Chen TH, Porter DW, Wu N, Yang F, Hamilton RF, Holian A (2014) Effect of multi-walled carbon nanotube surface modification on bioactivity in the c57bl/6 mouse model. Nanotoxicology 8(3):317–327. doi: 10.3109/17435390.2013.779757. Available from http://informahealthcare.com/doi/abs/10.3109/17435390.2013.779757.
- Schubauer-Berigan MK, Dahm MM, Yencken MS (2011) Engineered carbonaceous nanomaterials manufacturers in the United States: workforce size, characteristics, and feasibility of epidemiologic studies. J Occup Environ Med 53(6S):S62–S67Google Scholar
- Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, Hubbs AF, Mercer RR, Keohavong P, Sussman N, Jin J, Yin J, Stone S, Chen BT, Deye G, Maynard A, Castranova V, Baron PA, Kagan VE (2008) Inhalation vs. aspiration of single-walled carbon nanotubes in c57bl/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesisGoogle Scholar