Influence of the aggregation, concentration, and viscosity on the nanomagnetism of iron oxide nanoparticle colloids for magnetic hyperthermia
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Iron oxide nanoparticles have become ubiquitous in many biomedical applications, acting as core elements in an increasing number of therapeutic and diagnostic modalities. These applications mainly rely on their static and dynamic magnetic properties, through which they can be remotely actuated. However, little attention has been paid to understand the variation of the magnetic response of nanoparticles inside cells or tissues, despite of the remarkable changes reported to date. In this article, we provide some hints to analyze the influence of the biological matrix on the magnetism of iron oxide nanoparticles. To this aim, we propose the assessment of the heating efficiency of magnetic colloids against nanoparticle aggregation, concentration, and viscosity in order to mimic the fate of nanoparticles upon cell internalization.
KeywordsNanomagnetism Magnetic iron oxide nanoparticles Magnetic hyperthermia Dipolar interactions Aggregation Viscosiy Cell internalization Bioinspired nanomaterials
This work has been partially supported by European Commission (MULTIFUN, No. 262943), Spanish Ministry of Economy and Competitiveness (MAT2013-47395-C4-3-R), and Madrid Regional Government (NANOFRONTMAG-CM S2013/MIT-2850). F. J. T acknowledges financial support from Ramon y Cajal subprogram (RYC-2011-09617). We thank Dr. Gorka Salas for providing iron oxide nanoparticles, and Leonor de la Cueva and Rebeca Amaro for their technical assistance.
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