Structural organization of C60 fullerene, doxorubicin, and their complex in physiological solution as promising antitumor agents
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Specific features of structural self-organization of C60 fullerene (1 nm size range), antitumor antibiotic doxorubicin (Dox) and their complex in physiological solution (0.9 % NaCl) have been investigated by means of atomic-force microscopy, dynamic light scattering, and small-angle X-ray scattering. Significant ordering of the mixed system, C60 + Dox, was observed, suggesting the complexation between these drugs, and giving insight into the mechanism of enhancement of Dox antitumor effect on simultaneous administration with C60 fullerene.
KeywordsC60 fullerene Doxorubicin Physiological solution Atomic-force microscopy Dynamic light scattering Small-angle X-ray scattering
This work was supported, in part, by Russian Science Fund, Project No. 14-14-00328.
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