Sustained release of fungicide metalaxyl by mesoporous silica nanospheres

Research Paper
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Part of the following topical collections:
  1. Nanotechnology for Sustainable Development

Abstract

The use of nanomaterials for the controlled delivery of pesticides is nascent technology that has the potential to increase the efficiency of food production and decrease pollution. In this work, the prospect of mesoporous silica nanoparticles (MSN) for storage and controlled release of metalaxyl fungicide has been investigated. Mesoporous silica nanospheres with average particle diameters of 162 nm and average pore sizes of 3.2 nm were prepared by a sol–gel process. Metalaxyl molecules were loaded into MSN pores from an aqueous solution by a rotary evaporation method. The loaded amount of metalaxyl as evaluated by thermogravimetric analysis was about 14 wt%. Release of the fungicide entrapped in the MSN matrix revealed sustained release behavior. About 76 % of the free metalaxyl was released in soil within a period of 30 days while only 11.5 and 47 % of the metalaxyl contained in the MSN carrier was released in soil and water, respectively, within the same period. The study showed that MSN can be used to successfully store metalaxyl molecules in its mesoporous framework and significantly delay their release in soil.

Keywords

Mesoporous silica nanoparticles Metalaxyl Loading Sustained release 
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Notes

Acknowledgments

This research was supported by the German Academic Exchange Service (DAAD) and Jomo Kenyatta University of Agriculture and Technology (JKUAT).

References

  1. Al-Kady AS, Gaber M, Hussein MM, Ebeid EM (2011) Nanostructure-loaded mesoporous silica for controlled release of coumarin derivatives: a novel testing of the hyperthermia effect. Eur J Pharm Biopharm 77:66–74CrossRefGoogle Scholar
  2. Ambrogio MW, Thomas CR, Zhao Y-L, Zink JI, Stoddart JF (2011) Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine. Acc Chem Res 44(10):903–913. doi: 10.1021/ar200018x CrossRefGoogle Scholar
  3. Fernandes MC, Cox L, Hermosin MC, Cornejo J (2003) Adsorption–desorption of metalaxyl as affecting dissipation and leaching in soil role of mineral and organic components. Pest Manag Sci 59:545–552CrossRefGoogle Scholar
  4. Ghormade V, Deshpande MV, Paknikar KM (2011) Perspectives for nano-biotechnology enabled protection and nutrition of plants. Biotechnol Adv 29:792–803CrossRefGoogle Scholar
  5. Giles CH, Mac Ewan TH, Nakhwa SN, Smith D (1960) Studies in adsorption. Part XI. A system of classification of solution adsorption isotherms, and its use in diagnosis of adsorption mechanisms and in measurement of specific surface areas of solids. J Chem Soc 111:3973–3993CrossRefGoogle Scholar
  6. Li Z-Z, Xu S-A, Wen L-X, Liu F, Liu A-Q, Wang Q, Sun H-Y, Yu W, Chen J-F (2006) Controlled release of avermectin from porous hollow silica nanoparticles: influence of shell thickness on loading efficiency, UV-shielding property and release. J Controlled Release 111:81–88CrossRefGoogle Scholar
  7. Limnell T, Santos HA, Makila E, Heikkila T, Salonen J, Murzin DY, Kumar N, Laaksonen T, Peltonen L, Hirvonen J (2011) Drug delivery formulations of ordered mesoporous silica: comparison of three drug loading methods. J Pharm Sci 100(8):3294–3306. doi: 10.1002/jps.22577 CrossRefGoogle Scholar
  8. Liu Y, Yan I, Heiden P, Laks P (2001) Use of nanoparticles for controlled release of biocides in solid wood. J Appl Polym Sci 79:458–465CrossRefGoogle Scholar
  9. Liu F, Wen L-X, Li Z-Z, Yu W, Sun H-Y, Chen J-F (2006) Porous hollow silica nanoparticles as controlled delivery system for water-soluble pesticide. Mater Res Bull 41:2268–2275Google Scholar
  10. Monkiedje A, Ilori MO, Spiteller M (2002) Soil quality changes resulting from the application of the fungicides mefenoxam and metalaxyl to a sandy loam soil. Soil Biol Biochem 34:1939–1948CrossRefGoogle Scholar
  11. Nair R, Varghese SH, Nair BG, Maekawa T, Yoshida Y, Kumar DS (2010) Nanoparticulate material delivery to plants. J Plant Sci 179:154–163CrossRefGoogle Scholar
  12. Popovici RF, Seftel EM, Mihai GD, Popovici E, Voicu VA (2011) Controlled drug delivery system based on ordered mesoporous silica matrices of captopril as angiotensin-converting enzyme inhibitor drug. J Pharm Sci 100(2):704–714CrossRefGoogle Scholar
  13. Rodrıguez-Cruz MS, Andrades MS, Sanchez-Martın MJ (2008) Significance of the long-chain organic cation structure in the sorption of the penconazole and metalaxyl fungicides by organo clays. J Hazard Mater 160:200–207CrossRefGoogle Scholar
  14. Sukul P, Spiteller M (2001) Influence of biotic and abiotic factors on dissipating metalaxyl in soil. Chemosphere 45:941–947CrossRefGoogle Scholar
  15. Ukmar T, Maver U, Planinsek O, Kaucic V, Gaberscek M, Godec A (2011) Understanding controlled drug release from mesoporous silicates: theory and experiment. J Controlled Release 155:409–417CrossRefGoogle Scholar
  16. Wen L-X, Li Z-Z, Zou H-K, Liu A-Q, Chen J-F (2005) Controlled release of avermectin from porous hollow silica nanoparticles. Pest Manag Sci 61:583–590CrossRefGoogle Scholar
  17. Yang Y-W (2011) Towards biocompatible nanovalves based on mesoporous silica nanoparticles. Med Chem Commun 2:1033–1049. doi: 10.1039/c1md00158b CrossRefGoogle Scholar
  18. Zheng H, Shang Q (2005) Water suspension acetamiprid nanocapsule preparation and its repairing method. Chem. Abs. 143:73729Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of ChemistryJomo Kenyatta University of Agriculture & TechnologyNairobiKenya

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