Silver nanoparticles delivery system based on natural rubber latex membranes

  • Éder José GuidelliEmail author
  • Angela Kinoshita
  • Ana Paula Ramos
  • Oswaldo Baffa
Research Paper


The search for new materials for biomedical applications is extremely important. Here, we present results on the performance of a silver nanoparticles delivery system using natural rubber latex (NRL) as the polymeric matrix. Our aim was to obtain an optimized wound dressing by combining materials with potential healing action. The synthesis of silver nanoparticles and their characterization by UV–Vis spectroscopy, transmission electron microscopy, zeta potential, dynamic light scattering, and Fourier transform infrared spectroscopy (FTIR) are depicted. The NRL membranes are good matrix for silver nanoparticles and allow for their gradual release. The release of 30 nm silver nanoparticles by the NRL membranes depends on their mass percentage in NRL membranes. The total concentration of AgNP released by the NRL membranes was calculated. The AgNP attached to the cis-isoprene molecules in the NRL matrix remain attached to the membrane (~0.1 % w/w). So, only the AgNP bound to the non-rubber molecules are released. FTIR spectra suggest that non-rubber molecules, like aminoacids and proteins, associated with the serum fraction of the NRL may be attached to the surfaces of the released nanoparticles, thereby increasing the release of such molecules. The released silver nanoparticles are sterically stabilized, more stable and well dispersed. Because the serum fraction of the NRL is responsible for the angiogenic properties of the matrix, the silver nanoparticles could increment the angiogenic properties of NRL. This biomaterial has desirable properties for the fabrication of a wound dressing with potential healing action, since it combines the angiogenic and antibacterial properties of the silver nanoparticles with the increased angiogenic properties of the NRL.

Graphical Abstract

The AgNP attached to the cis-isoprene molecules remain in the NRL matrix and only the AgNP bound to the non-rubber molecules (NRL serum fraction) are released. The released AgNP are sterically stabilized, more stable and well dispersed.


Natural rubber latex Drug delivery system Silver nanoparticles Wound dressing 



The authors are grateful to C. A. Brunello for technical assistance, Professor A. S. Ito for the use of his UV–Vis spectrometer, Professor. M. E. D. Zaniquelli for the use of the zetaSizer system, and Dr. Cynthia Maria de Campos Prado Manso for language revision. This study was supported by the Brazilian agencies: FAPESP, CNPq, and CAPES.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Éder José Guidelli
    • 1
    Email author
  • Angela Kinoshita
    • 2
  • Ana Paula Ramos
    • 3
  • Oswaldo Baffa
    • 1
  1. 1.Universidade de São Paulo/FFCLRP-DFRibeirão PretoBrazil
  2. 2.Universidade do Sagrado CoraçãoBauruBrazil
  3. 3.Universidade de São Paulo/FFCLRP-DQRibeirão PretoBrazil

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