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Applications of polymeric micelles with tumor targeted in chemotherapy

  • Hui Ding
  • Xiaojun Wang
  • Song Zhang
  • Xinli LiuEmail author
Review

Abstract

Polymeric micelles (PMs) have gained more progress as a carrier system with the quick development of biological and nanoparticle techniques. In particular, PMs with smart targeting can deliver anti-cancer drugs directly into tumor cells at a sustained rate. PMs with core–shell structure (with diameters of 10 ~ 100 nm) have been prepared by a variety of biodegradable and biocompatible polymers via a self-assembly process. The preparation of polymeric micelles with stimuli-responsive block copolymers or modification of target molecules on polymeric micelles’ surface are able to significantly improve the efficiency of drug delivery. Polymeric micelles, which have been considered as a novel promising drug carrier for cancer therapeutics, are rapidly evolving and being introduced in an attempt to overcome several limitations of traditional chemotherapeutics, including water solubility, tumor-specific accumulation, anti-tumor efficacy, and non-specific toxicity. This review describes the preparation of polymeric micelles and the targeted modification which greatly enhance the effects of chemotherapeutic agents.

Keywords

Polymeric micelles Chemotherapy Tumor targeting Stimuli-responsive micelles 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Hui Ding
    • 1
  • Xiaojun Wang
    • 1
  • Song Zhang
    • 1
  • Xinli Liu
    • 1
    • 2
    Email author
  1. 1.Shandong Provincial Key Laboratory of Microbial EngineeringShandong Polytechnic UniversityJinanPeople’s Republic of China
  2. 2.Food and Bioengineering InstituteShandong Polytechnic UniversityJinanPeople’s Republic of China

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