Nanomaterial inhalation exposure from nanotechnology-based cosmetic powders: a quantitative assessment
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In this study we quantified exposures to airborne particles ranging from 14 nm to 20 μm due to the use of nanotechnology-based cosmetic powders. Three nanotechnology-based and three regular cosmetic powders were realistically applied to a mannequin’s face while measuring the concentration and size distribution of inhaled aerosol particles. Using these data we calculated that the highest inhaled particle mass was in the coarse aerosol fraction (2.5–10 μm), while particles <100 nm made minimal contribution to the inhaled particle mass. For all powders, 85–93 % of aerosol deposition occurred in the head airways, while <10 % deposited in the alveolar and <5 % in the tracheobronchial regions. Electron microscopy data suggest that nanomaterials were likely distributed as agglomerates across the entire investigated aerosol size range (14 nm–20 μm). Thus, investigation of nanoparticle health effects should consider not only the alveolar region, but also other respiratory system regions where substantial nanomaterial deposition during the actual nanotechnology-based product use would occur.
KeywordsNanoaerosol Consumer products Nanoparticles Personal exposure Safety of nanotechnology
This research was supported in part by the National Institute of Environmental Health Sciences (NIEHS) sponsored University of Medicine and Dentistry of New Jersey (UMDNJ) Center for Environmental Exposures and Disease (Grant # P30ES005022, joint grant between US Environmental Protection Agency and UK Natural Environment Research Council (NERC) (Grants # 83469302 and # NE/H012893), and the New Jersey Agriculture and Experiment Station (NJAES) at Rutgers University. The views expressed in this paper are solely those of the authors and do not necessarily reflect the views of the funding agencies.
Conflict of interest
The authors declare no conflict of interest.
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