Journal of Nanoparticle Research

, Volume 13, Issue 9, pp 4267–4276 | Cite as

Silver nanoparticles embedded in amine-functionalized silicate sol–gel network assembly for sensing cysteine, adenosine and NADH

Research Paper
First Online:
Received:
Accepted:

Abstract

Silver nanoparticles embedded in amine-functionalized silicate sol–gel network were synthesized and used for sensing biomolecules such as cysteine, adenosine, and β-nicotinamide adenine dinucleotide (NADH). The sensing of these biomolecules by the assembly of silver nanoparticles was triggered by the optical response of the surface plasmon resonance (SPR) of the silver nanoparticles. The optical sensor exhibited the lowest detection limit (LOD) of 5, 20, and 5 μM for cysteine, adenosine, and NADH, respectively. The sensing of biomolecules in the micromolar range by using the amine-functionalized silicate sol–gel embedded silver nanoparticles was studied in the presence of interference molecules like uridine, glycine, guanine, and guanosine. Thus, the present approach might open up a new avenue for the development of silver nanoparticles-based optical sensor devices for biomolecules.

Keywords

Silver nanoparticles Silicate sol–gel Biomolecules Sensor Diagnostics Nanomedicine 
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Notes

Acknowledgments

R.R. acknowledges the financial support from the Department of Science and Technology (DST), New Delhi, and G.M. is a recipient of the CSIR-SRF fellowship.

Supplementary material

11051_2011_372_MOESM1_ESM.doc (4.2 mb)
Supplementary material 1 (DOC 4334 kb)

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Centre for Photoelectrochemistry, School of ChemistryMadurai Kamaraj UniversityMaduraiIndia

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