Journal of Nanoparticle Research

, Volume 13, Issue 4, pp 1677–1688 | Cite as

Biodegradable thermoresponsive polymeric magnetic nanoparticles: a new drug delivery platform for doxorubicin

  • Nidhi Andhariya
  • Bhupendra Chudasama
  • R. V. Mehta
  • R. V. Upadhyay
Research Paper

Abstract

The use of nanoparticles as drug delivery systems for anticancer therapeutics has great potential to revolutionize the future of cancer therapy. The aim of this study is to construct a novel drug delivery platform comprising a magnetic core and biodegradable thermoresponsive shell of tri-block-copolymer. Oleic acid-coated Fe3O4 nanoparticles and hydrophilic anticancer drug “doxorubicin” are encapsulated with PEO–PLGA–PEO (polyethylene oxide–poly d, l lactide-co-glycolide–polyethylene oxide) tri-block-copolymer. Structural, magnetic, and physical properties of Fe3O4 core are determined by X-ray diffraction, vibrating sample magnetometer, and transmission electron microscopy techniques, respectively. The hydrodynamic size of composite nanoparticles is determined by dynamic light scattering and is found to be ~36.4 nm at 25 °C. The functionalization of magnetic core with various polymeric chain molecules and their weight proportions are determined by Fourier transform infrared spectroscopy and thermogravimetric analysis, respectively. Encapsulation of doxorubicin into the polymeric magnetic nanoparticles, its loading efficiency, and kinetics of drug release are investigated by UV–vis spectroscopy. The loading efficiency of drug is 89% with a rapid release for the initial 7 h followed by the sustained release over a period of 36 h. The release of drug is envisaged to occur in response to the physiological temperature by deswelling of thermoresponsive PEO–PLGA–PEO block-copolymer. This study demonstrates that temperature can be exploited successfully as an external parameter to control the release of drug.

Keywords

Biocompatible materials Encapsulation Drug delivery IR spectroscopy Thermoresponsive polymer Cancer therapy Nanomedicine 

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Nidhi Andhariya
    • 1
  • Bhupendra Chudasama
    • 2
  • R. V. Mehta
    • 1
  • R. V. Upadhyay
    • 3
  1. 1.Department of PhysicsBhavnagar UniversityBhavnagarIndia
  2. 2.School of Physics & Materials ScienceThapar UniversityPatialaIndia
  3. 3.P.D. Patel Institute of Applied SciencesCharotar University of Science and TechnologyChangaIndia

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