Journal of Nanoparticle Research

, Volume 12, Issue 2, pp 663–673 | Cite as

Mesoporous silica-coated NaYF4:Yb3+, Er3+ particles for drug release

  • Deyan Kong
  • Yong Fan
  • Cuimiao Zhang
  • Jun Lin
Research Paper


NaYF4:Yb3+, Er3+ nanoparticles were successfully prepared by a polyol process using diethyleneglycol (DEG) as solvent. These NaYF4:Yb3+, Er3+ nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer EO20PO70EO20 (P 123) as structure-directing agent and other materials. The composites can load ibuprofen and release the drug in the phosphate buffer solution (PBS). The composites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composites have the mesoporous structure. In addition, the composites emit red fluorescence (from Er3+) under 980 nm near infrared laser excitation, which can be used as fluorescent probes in the drug-delivery system.


Up-conversion fluorescence Drug release Mesoporous silica Drug delivery Nanomedicine 



This project is financially supported by the National Basic Research Program of China (2007CB935502) and the National Natural Science Foundation of China (NSFC 50702057, 50872131, 00610227).


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunPeople’s Republic of China
  2. 2.Graduate School of the Chinese Academy of SciencesBeijingPeople’s Republic of China

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