Mesoporous silica-coated NaYF4:Yb3+, Er3+ particles for drug release
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NaYF4:Yb3+, Er3+ nanoparticles were successfully prepared by a polyol process using diethyleneglycol (DEG) as solvent. These NaYF4:Yb3+, Er3+ nanoparticles can be coated with mesoporous silica using nonionic triblock copolymer EO20PO70EO20 (P 123) as structure-directing agent and other materials. The composites can load ibuprofen and release the drug in the phosphate buffer solution (PBS). The composites were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), nitrogen absorption/desorption isotherms, fluorescence spectra, and UV/Vis absorption spectra, respectively. The composites have the mesoporous structure. In addition, the composites emit red fluorescence (from Er3+) under 980 nm near infrared laser excitation, which can be used as fluorescent probes in the drug-delivery system.
KeywordsUp-conversion fluorescence Drug release Mesoporous silica Drug delivery Nanomedicine
This project is financially supported by the National Basic Research Program of China (2007CB935502) and the National Natural Science Foundation of China (NSFC 50702057, 50872131, 00610227).
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