Combined synthesis and in situ coating of nanoparticles in the gas phase
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Abstract
Combined gas phase synthesis and coating of sodium chloride (NaCl) and lactose nanoparticles has been developed using an aerosol flow reactor. Nano-sized core particles were produced by the droplet-to-particle method and coated in situ by the physical vapour deposition of L-leucine vapour. The saturation of L-leucine in the reactor determined the resulting particle size and size distribution. In general, particle size increased with the addition of L-leucine and notable narrowing of the core particle size distribution was observed. In addition, homogeneous nucleation of the vapour, i.e. formation of pure L-leucine particles, was observed depending on the saturation conditions of L-leucine as well as the core particle characteristics. The effects of core particle properties, i.e. size and solid-state characteristics, on the coating process were studied by comparing the results for coated NaCl and lactose particles. During deposition, L-leucine formed a uniform coating on the surface of the core particles. The coating stabilised the nanoparticles and prevented the sintering of particles during storage.
Keywords
Aerosol Coating Gas-phase Nanoparticles Pharmaceutical ProcessingReferences
- Bodmeier R, Chen H (1990) Indomethacin polymeric nanosuspensions prepared by microfluidization. J Control Release 12:223–233CrossRefGoogle Scholar
- Caruso F (2001) Nanoengineering of particle surfaces. Adv Mater 13:11–22CrossRefGoogle Scholar
- Chen C-C, Tao C-J, Shu H-J (2000) Heterogeneous nucleation on n-butanol vapor on submicrometer charged and neutral particles of lactose and monosodium glutamate. J Colloid Interface Sci 224:11–22CrossRefGoogle Scholar
- Chew NYK, Shekunov BY, Tong HHY, Chow AHL, Savage C, Wu J, Chan H-K (2005) Effect of amino acids on the dispersion of disodium cromoglycate powders. J Pharm Sci 94:2289–2300CrossRefGoogle Scholar
- Couvreur P, Dubernet C, Puisieux F (1995) Controlled drug delivery with nanoparticles: current possibilities and future trends. Eur J Pharm Biopharm 41:2–13Google Scholar
- Cruz CN, Pandis SN (1999) Condensation of organic vapors on an externally mixed aerosol population. Aerosol Sci Technol 31:392–407CrossRefGoogle Scholar
- Davies R, Schurr GA, Meenan P, Nelson RD, Bergna HE, Brevett CA, Goldbaum RH (1998) Engineered particle surfaces. Adv Mater 10:1264–1270CrossRefGoogle Scholar
- De Jaeghere F, Allémann E, Doelker E, Gurny R (2001) pH-dependent dissolving nano- and microparticles for improved peroral delivery of highly lipophilic compound in dogs. AAPS Pharm. Sci 3 (Article 8)Google Scholar
- Flagan RC, Lunden MM (1995) Particle structure control in nanoparticle synthesis from the vapor phase. Mater Sci Eng A204:113–124Google Scholar
- Flagan RC, Seinfeld JH (1988) Fundamentals of air pollution engineering. Prentice Hall, Englewood Cliffs, NJ, p 542Google Scholar
- Foutou GP, Kodas TT, Anderson B (2000) Coating titania aerosol particles with ZrO2, Al2O3, and SiO2/ZrO2 in gas phase process. Aerosol Sci Technol 33:557–571CrossRefGoogle Scholar
- Fuchs NA, Sutugin AG (1971) High-dispersed aerosols. In: Hidy GM, Brock JR (eds) Topics in current aerosol research. Pergamon Press, New York, pp 1–60Google Scholar
- Hinds WC (1999) Aerosol technology, 2nd edn. Wiley, New YorkGoogle Scholar
- Incropera FP, DeWitt DP (2002) Fundamentals of heat and mass transfer, 5th edn. Wiley, New YorkGoogle Scholar
- Jain S, Fotou GP, Kodas TT (1997) A theoretical study on gas-phase coating of aerosol particles. J Colloid Interface Sci 185:26–38CrossRefGoogle Scholar
- Kreuter J (2001) Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 47:65–81CrossRefGoogle Scholar
- Lechuga-Ballesteros D, Kuo M-C (2001) Dry powder compositions having improved dispersity. WO 01/32144, 10 May 2001Google Scholar
- Liversidge GG, Cundy KC (1995) Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int J Pharm 125:91–97CrossRefGoogle Scholar
- Mayville FC, Partch RE, Matijevic E (1987) Preparation of uniform spherical titania particles coated with polyurea by aerosol technique. J Colloid Interface Sci 120:135–139CrossRefGoogle Scholar
- Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H, ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2:8CrossRefGoogle Scholar
- Ohring M (1992) The materials science of thin films. Academic Press, CAGoogle Scholar
- Parrott EI (1986) Milling. In: Lachmann L, Lieberman HA, Kanig JL (eds) The theory and practice of industrial pharmacy. Lea and Febiger, Philadelphia, PA, p 21Google Scholar
- Podczeck F (1999) The influence of particle size distribution and surface roughness of carrier particles on the in vitro properties of dry powder inhalations. Aerosol Sci Technol 31:301–321CrossRefGoogle Scholar
- Porstendörfer J, Scheibel HG, Pohl FG, Preining O, Reischl G, Wagner PE (1985) Heterogeneous nucleation of water vapour on monodispersed Ag and NaCl with diameters between 6 and 18 nm. J Aerosol Sci 4:65–79CrossRefGoogle Scholar
- Raula J, Kuivalainen A, Lähde A, Antopolsky M, Kansikas J, Kauppinen EI (2007) Synthesis of L-leucine nanoparticles via physical vapor deposition at varying saturation conditions. J Aerosol Sci 38:1172–1184CrossRefGoogle Scholar
- Raula J, Lähde A, Kauppinen EI (2008) A novel gas phase method for the combined synthesis and coating of pharmaceutical particles. Pharm Res 25:242–245CrossRefGoogle Scholar
- Ravi Kumar MNV (2000) Nano and microparticles as controlled drug delivery devices. J Pharm Sci 3:234–258Google Scholar
- Seinfeld JH, Pandis SN (1986) Atmospheric chemistry and physics: from air pollution to climate change. Wiley, New York, p 654Google Scholar
- Škapin S, Matijevic' E (2004) Preparation and coating of finely dispersed drugs. Loratadine and Danazol. J Colloid Interface Sci 272:90–98CrossRefGoogle Scholar
- Staniforth JN (2000) Carrier particles for the use in dry powder inhalers. US Patent 6,153,224Google Scholar
- Svec HJ, Clyde DD (1965) Vapor pressures of some alpha-amino acids. J Chem Eng Data 10:151–152CrossRefGoogle Scholar
- Yang J, Sliva A, Banerjee A, Dave RN, Pfeffer R (2005) Dry particle coating for improving the flowability of cohesive powders. Powder Technol 158:21–33CrossRefGoogle Scholar
- Zhang L, Ranade MB, Gentry JW (2004) Formation of organic coating on ultrafine silver particles using a gas-phase process. J Aerosol Sci 35:457–471CrossRefGoogle Scholar