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Journal of Nanoparticle Research

, Volume 9, Issue 5, pp 901–908 | Cite as

Preparation of nano-hydroxyapatite/poly(l-lactide) biocomposite microspheres

  • Xueyu Qiu
  • Yadong Han
  • Xiuli Zhuang
  • Xuesi Chen
  • Yuesheng Li
  • Xiabin Jing
Article

Abstract

Nano-hydroxyapatite (HA)/poly(l-lactide) (PLLA) composite microspheres with relatively uniform size distribution were prepared by a solid-in-oil-in-water (s/o/w) emusion solvent evaporation method. The encapsulation of the HA nanopaticles in microshperes was significantly improved by grafting PLLA on the surface of the HA nanoparticles (p-HA) during emulsion process. This procedure gave a possibility to obtain p-HA/PLLA composite microspheres with uniform morphology and the encapsulated p-HA nanoparticle loading reached up to 40 wt% (33 wt% of pure HA) in the p-HA/PLLA composite microspheres. The microstructure of composite microspheres from core-shell to single phase changed with the variation of p-HA to PLLA ratios. p-HA/PLLA composite microspheres with the diameter range of 2–3 μm were obtained. The entrapment efficiency of p-HA in microspheres could high up to 90 wt% and that of HA was only 13 wt%. Surface and bulk characterizations of the composite microspheres were performed by measurements such as wide angle X-ray diffraction (WAXD), thermal gravimetric analysis (TGA), environmental scanning electron microscope (ESEM) and transmission electron microscopy (TEM).

Keywords

hydroxyapatite polylactide composite microsphere surface modification surface grafting emulsion 

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Notes

Acknowledgements

This project was financially supported by the National Natural Science Foundation of China (20574066), the National Fund for Distinguished Young Scholars (50425309) and the International Cooperation fund of Science and Technology (Key project 2005DFA50290).

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Xueyu Qiu
    • 1
  • Yadong Han
    • 1
  • Xiuli Zhuang
    • 1
  • Xuesi Chen
    • 1
  • Yuesheng Li
    • 1
  • Xiabin Jing
    • 1
  1. 1.State Key Laboratory of Polymer Physics and chemistry, Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchunP.R. China

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