Journal of Nanoparticle Research

, Volume 8, Issue 6, pp 1017–1026 | Cite as

Stabilization of Pt nanoparticles by single stranded DNA and the binary assembly of Au and Pt nanoparticles without hybridization

  • J. Yang
  • Jim Yang Lee
  • Heng-Phon Too
  • Gan-Moog Chow
  • Leong M. Gan


The non-specific interaction between single stranded DNA (ssDNA) and 12 nm Pt nanoparticles is investigated in this work. The data show a strong and non-specific interaction between the two which can be exploited for the stabilization of Pt nanoparticles in aqueous solutions. Based on the experimental findings, a non-hybridization based protocol to assemble 17 nm Au and Pt nanoparticles (12 nm cubic and 3.6 nm spherical) by single-stranded DNA was developed. Transmission electron microscopy (TEM) and UV–visible spectroscopy confirmed that Au and Pt nanoparticles could be assembled by the non-specific interaction in an orderly manner. The experimental results also caution against the potential pitfalls in using DNA melting point analysis to infer metal nanoparticle assembly by DNA hybridization.


DNA Platinum nanoparticles non-specific interaction assembly melting point 


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The authors would like to acknowledge the financial support from Agency for Science, Technology & Research (project number 022-101-0038) and the Singapore-MIT Alliance. JY would like to acknowledge the National University of Singapore for his research scholarship.


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Copyright information

© Springer 2005

Authors and Affiliations

  • J. Yang
    • 1
  • Jim Yang Lee
    • 1
    • 2
  • Heng-Phon Too
    • 2
    • 3
  • Gan-Moog Chow
    • 2
    • 4
  • Leong M. Gan
    • 5
  1. 1.Department of Chemical and Biomolecular EngineeringNational University of Singapore Singapore
  2. 2.Singapore-MIT AllianceNational University of Singapore Singapore
  3. 3.Department of BiochemistryNational University of Singapore Singapore
  4. 4.Department of Materials ScienceNational University of Singapore Singapore
  5. 5.Institute of Materials Research and Engineering Singapore

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