Natural Computing

, Volume 5, Issue 2, pp 183–202

A DNA Superstructure-based Replicator without Product Inhibition


DOI: 10.1007/s11047-005-4465-x

Cite this article as:
Zhang, D.Y. & Yurke, B. Nat Comput (2006) 5: 183. doi:10.1007/s11047-005-4465-x


A monomer structure based on a hairpin loop is described that can be linked via short oligonucleotide sequences (linkers) to form polymers. Independence of linked monomers allow for exponential complexity of the polymer structure. A method is described wherein the polymer structure can be replicated semi-conservatively with fidelity, given a source of monomer structures and linkers. Furthermore, the separation of the product from the parent allows for exponential amplification. These steps are achieved by secondary structure constraints and toehold-mediated strand displacement, and occur in the absence of enzymes. The parallel polymerization allows for replication to be achieved in O(log N) time, as opposed to O(N) from a processive process.


DNA based polymers DNA motors self-replication 

Copyright information

© Springer 2006

Authors and Affiliations

  1. 1.Caltech M/C 136-93California Institute of TechnologyPasadenaUSA
  2. 2.Bell LaboratoriesMurray HillUSA

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