Disseminated Phaeohyphomycosis Caused by Curvularia tuberculata in a Previously Healthy Man

  • Vasin VasikasinEmail author
  • Worapong Nasomsong
  • Chutika Srisuttiyakorn
  • Wat Mitthamsiri
  • Nittha Oer-Areemitr
  • Dhitiwat Changpradub
Original Paper


Disseminated phaeohyphomycosis is an extremely rare clinical syndrome, especially in a host without apparent immunological defect. Here, we report a case of disseminated phaeohyphomycosis in a 22-year-old previously healthy man who showed nonmassive hemoptysis from diffuse lung nodules and cavities, together with a hard palate ulcer and generalized subcutaneous nodules. Histopathology, cultures and subsequent molecular assay from two different sites confirmed Curvularia tuberculata infection. The patient was successfully treated with amphotericin B and itraconazole.


Ascomycota Mycoses Thailand 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest. The authors alone are responsible for the content and writing of this paper.


  1. 1.
    Revankar SG, Sutton DA. Melanized fungi in human disease. Clin Microbiol Rev. 2010;23(4):884–928.CrossRefGoogle Scholar
  2. 2.
    Ajello L, Georg LK, Steigbigel RT, Wang CJ. A case of phaeohyphomycosis caused by a new species of Phialophora. Mycologia. 1974;66:490–8.CrossRefGoogle Scholar
  3. 3.
    Revankar SG. Phaeohyphomycosis. Infect Dis Clin N Am. 2006;20:609–20.CrossRefGoogle Scholar
  4. 4.
    Madrid H, da Cunha KC, Gene J, Dijksterhuis J, Cano J, Sutton DA, et al. Novel Curvularia species from clinical specimens. Persoonia. 2014;33:48–60.CrossRefGoogle Scholar
  5. 5.
    Jain B. Two new species of Curvularia. Trans Br Mycol Soc. 1962;45:539–44.CrossRefGoogle Scholar
  6. 6.
    Manamgoda DS, Cai L, Bahkali AH, Chukeatirote E, Hyde KD. Cochliobolus: an overview and current status of species. Fungal Divers. 2011;51:3–42.CrossRefGoogle Scholar
  7. 7.
    Manamgoda DS, Rossman AY, Castlebury LA, Chukeatirote E, Hyde K. A taxonomic and phylogenetic re-appraisal of the genus Curvularia (Pleosporaceae): human and plant pathogens. Phytotaxa. 2015;212:24.CrossRefGoogle Scholar
  8. 8.
    Revankar SG, Patterson JE, Sutton DA, Pullen R, Rinaldi MG. Disseminated phaeohyphomycosis: review of an emerging mycosis. Clin Infect Dis. 2002;34:467–76.CrossRefGoogle Scholar
  9. 9.
    Tessari G, Forni A, Ferretto R, Solbiati M, Faggian G, Mazzucco A, et al. Lethal systemic dissemination from a cutaneous infection due to Curvularia lunata in a heart transplant recipient. J Eur Acad Dermatol Venereol. 2003;17:440–2.CrossRefGoogle Scholar
  10. 10.
    Sivanesan A. The teleomorph of Curvularia tuberculata. Trans Br Mycol Soc. 1985;84:548–51.CrossRefGoogle Scholar
  11. 11.
    Chowdhary A, Meis JF, Guarro J, de Hoog GS, Kathuria S, Arendrup MC, et al. ESCMID and ECMM joint clinical guidelines for the diagnosis and management of systemic phaeohyphomycosis: diseases caused by black fungi. Clin Microbiol Infect. 2014;20(Suppl 3):47–75.CrossRefGoogle Scholar
  12. 12.
    Shelton BG, Kirkland KH, Flanders WD, Morris GK. Profiles of airborne fungi in buildings and outdoor environments in the United States. Appl Environ Microbiol. 2002;68:1743–53.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of MedicinePhramongkutklao HospitalBangkokThailand

Personalised recommendations