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Deep Cutaneous Neoscytalidium dimidiatum Infection: Successful Outcome with Amphotericin B Therapy

  • Shih-Jyun Yang
  • Chau-Yee Ng
  • Ting-Shu Wu
  • Po-Yen Huang
  • Yen-Mu Wu
  • Pei-Lun Sun
Case Report
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Abstract

Phaeohyphomycosis is a term used to describe a heterogenous group of cutaneous and systemic mycotic infections caused by melanized fungi. Many fungi have been reported as pathogens of this disease. The disease spectrum ranges from superficial cutaneous infections, deep cutaneous infections, to systemic infections with internal organ involvement. We report two cases of deep cutaneous phaeohyphomycosis on the foot clinically presenting as cellulitis with abscess formation. The pathogens were isolated from the lesion and both were identified as Neoscytalidium dimidiatum by their colony morphology, microscopic features, and sequences of internal transcribed spacers of ribosomal DNA. Both patients did not respond to the therapy with voriconazole and itraconazole, but improved after intravenous amphotericin B.

Keywords

Neoscytalidium dimidiatum Scytalidium dimidiatum Phaeohyphomycosis Skin Deep fungal infection 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Shih-Jyun Yang
    • 1
    • 3
  • Chau-Yee Ng
    • 1
    • 3
  • Ting-Shu Wu
    • 2
    • 3
  • Po-Yen Huang
    • 2
    • 3
  • Yen-Mu Wu
    • 2
    • 3
  • Pei-Lun Sun
    • 1
    • 3
    • 4
  1. 1.Department of DermatologyChang Gung Memorial HospitalTaoyuanTaiwan
  2. 2.Division of Infectious Diseases, Department of Internal MedicineChang Gung Memorial HospitalLinkouTaiwan
  3. 3.College of MedicineChang Gung UniversityTaoyuanTaiwan
  4. 4.Research Laboratory of Medical Mycology, Department of DermatologyChang Gung Memorial HospitalTaoyuanTaiwan

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