Chromoblastomycosis Caused by Fonsecaea nubica: First Report in Northern China and Literature Review
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Chromoblastomycosis is found worldwide with higher incidence in tropical and subtropical regions. Fonsecaea spp. is one of the major causative agents of this disease. First case of chromoblastomycosis due to Fonsecaea nubica in Northern China is reported in a 75-year-old Chinese male. We firstly summarized molecular identification methods of Fonsecaea spp. and all the strains of F. nubica reported in the literature. Sequencing of internal transcribed spacer alone and/or combined with actin (ACT1), partial cell division cycle (CDC42) and partial beta-tubulin (BT2) were most commonly used to identify species, while lactase (Lac), homogentisate (HmgA) and polyketide synthase (PKS1) were also used in some cases. Most strains were isolated from South America and Eastern China. Five clinical cases of chromoblastomycosis due to F. nubica from Asia and Europe were also reviewed. All the five patients were male, over 30 years old, and their lesions occurred after trauma.
KeywordsChromoblastomycosis Fonsecaea nubica Species identification Molecular methods
The authors thank Sushmita Pradhan (Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China) who corrected the English grammar of the article.
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Conflict of interest
All authors declare no conflict of interest.
- 6.Gomes RR, Vicente VA, Azevedo CM, Salagado CG, da Silva MB, Queiroz-Telles F, et al. Molecular epidemiology of agents of human chromoblastomycosis in Brazil with the description of two novel species. PloS Negl Trop Dis. 2017;10(11):e0005315.Google Scholar
- 10.Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi, 2nd edn. Approved standard. CLSI document M38-A2. Wayne, PA, USA: Clinical and Laboratory Standards Institute; 2008.Google Scholar
- 30.White TJ, Bruns T, Lee S, Taylor J. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. In: Innis MA, Gelfand DH, Sninsky J, White TJ, editors. PCR protocols: a guide to methods and applications. New York: Academic Press; 1990. p. 315–22.Google Scholar