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Mycopathologia

, Volume 184, Issue 1, pp 141–146 | Cite as

Rhinocerebral Zygomycosis Due to a Lichtheimia ramosa Infection in a Calf: Neural Spread Through the Olfactory Nerves

  • Yusuke Tanaka
  • Takahito Toyotome
  • Hisashi Inokuma
  • Ken-ichi Watanabe
  • Yoshiyasu Kobayashi
  • Noriyuki HoriuchiEmail author
Short Communication

Abstract

Here, we report a case of rhinocerebral zygomycosis due to a Lichtheimia ramosa infection in a calf. A histopathological examination revealed that a fungus had invaded the brain through the olfactory nerves. Lichtheimia ramosa was detected by polymerase chain reaction analysis of DNA extracted from formalin-fixed paraffin-embedded samples of the affected tissue. This is the first case of rhinocerebral zygomycosis to involve cattle. Also, this is the first such case to involve fungal invasion into the central nervous system through the cranial nerve itself, rather than through perineural tissue.

Keywords

Cattle Lichtheimia ramosa Neural spread Rhinocerebral Zygomycosis 

Notes

Acknowledgements

We thank Mrs. Tomikawa for her technical assistance.

Compliance with Ethical Standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Human and Animal Rights

This study did not contain any experiments involving human subjects. In addition, no animal experiments were performed in this study. The animal described in the present article was submitted as a necropsy sample after its death, and all of the procedures applied to the animal were approved by the Committee on the Ethics of Animal Experiments of Obihiro University of Agriculture and Veterinary Medicine (Permit Number: 29-153). All applicable international, national, and institutional guidelines for the care of animals were followed.

Supplementary material

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Supplementary material 1 (TIFF 10040 kb)
11046_2018_296_MOESM2_ESM.pdf (314 kb)
Supplementary material 2 (PDF 314 kb)

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Veterinary MedicineObihiro University of Agriculture and Veterinary MedicineObihiroJapan
  2. 2.Research Center for Global AgromedicineObihiro University of Agriculture and Veterinary MedicineObihiro-ShiJapan

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