Aspergillus terreus Causing Probable Invasive Aspergillosis in a Patient with Cystic Fibrosis
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Aspergillus terreus may colonize the airways of patients with cystic fibrosis (CF). Whether this merits antifungal treatment is still unclear due to heterogeneous reports regarding its pathogenic potential. Although allergic manifestations are documented, invasive aspergillosis (IA) caused by A. terreus has not been described. We present here one case of probable IA caused by A. terreus, highlighting its role as an emerging agent of IA in CF patients. Voriconazole was effective, and the patient was healthy after 12 weeks of treatment. Serial determination of serum galactomannan level and periodic cultures from respiratory specimens may help in monitoring CF patients by identifying such pathogens. Further studies on the fungal species colonizing the CF airways are warranted, especially in India. This case report suggests A. terreus as a potential agent of IA which should not be ignored, particularly in this patient group.
KeywordsAspergillus terreus Cystic fibrosis Invasive aspergillosis Emerging
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Conflict of interest
The authors declare that they have no conflict of interest.
This study was based on retrospective data analysis and did not include any intervention besides standard of care during hospitalization.
Informed consent was obtained from the parents of the patient included in this study.
- 1.Ashavaid TF, Raghavan R, Dhairyawan P, et al. Cystic fibrosis in India: a systematic review. J Assoc Phys India. 2012;60:39–41.Google Scholar
- 5.Mosquera RA, Estrada L, Clements RM, Jo CK. Early diagnosis and treatment of invasive pulmonary aspergillosis in a patient with cystic fibrosis. BMJ Case Rep. 2013;2013:bcr2013201360.Google Scholar
- 10.CLSI. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi; approved standard-second edition. CLSI document M38-A2. Wayne, PA: Clinical and Laboratory Standards Institute 2008.Google Scholar