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Mycopathologia

, Volume 184, Issue 1, pp 155–158 | Cite as

Combined Medical and Surgical Management of Hepatic Mucormycosis in an Adult with Acute Myeloid Leukemia: Case Report and Review of the Literature

  • Mansi Shah
  • Jeremy Nel
  • Abdulrahman Almansouri
  • David Van Duin
  • David A. GerberEmail author
Case Report
  • 102 Downloads

Abstract

Hepatic mucormycosis is a disease caused by a ubiquitous fungus which is especially important in patients with hematologic malignancies. We present a case of an adult patient with acute myeloid leukemia who developed the infection after undergoing chemotherapy. His successful management was an integrated approach of a minimally invasive surgical resection with anti-fungal therapy. We describe the management of this patient and a review of the literature.

Keywords

Hepatic mucormycosis Laparoscopic surgery Hematologic malignancy 

Notes

Authors’ Contributions

MS contributed to data collection, literature review and writing the manuscript; JN assisted with writing the manuscript; AA assisted with data collection; DVD assisted with writing and editing the manuscript; DAG was involved in study design, writing and editing the manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed Consent

For this type of study, formal consent is not required.

References

  1. 1.
    Abboud CS, Bergamasco MD, Baía CE, Lallée MP, Zan AS, Zamorano MM, Pereira OI, Mies S. Case report of hepatic mucormycosis after liver transplantation: successful treatment with liposomal amphotericin B followed by posaconazole sequential therapy. Transplant Proc. 2012;44(8):2501–2.CrossRefPubMedGoogle Scholar
  2. 2.
    Pagano L, Ricci P, Tonso A, Nosari A, Cudillo L, Montillo M, Cenacchi A, Pacilli L, Fabbiano F, Del Favero A. Mucormycosis in patients with haematological malignancies: a retrospective clinical study of 37 cases. GIMEMA Infection Program (Gruppo Italiano Malattie Ematologiche Maligne dell’Adulto). Br J Haematol. 1997;99(2):331–6.CrossRefPubMedGoogle Scholar
  3. 3.
    Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Schaufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP, Walsh TJ. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41(5):634–53.CrossRefPubMedGoogle Scholar
  4. 4.
    Khan AA, Kumaran V, Jain D, Siraj F, Aggarwal S. Hepatic mucormycosis in a patient of acute lymphoblastic leukemia: a case report with literature review. Indian J Hematol Blood Transfus. 2013;29(2):96–8.CrossRefPubMedGoogle Scholar
  5. 5.
    Vallaeys JH, Praet MM, Roels HJ, Van Marck E, Kaufman L. The Budd-Chiari syndrome caused by a zygomycete. A new pathogenesis of hepatic vein thrombosis. Arch Pathol Lab Med. 1989;113(10):1171–4.PubMedGoogle Scholar
  6. 6.
    Yang C, Friess SH, Dehner LP. Hepatic mucormycosis mimicking veno-occlusive disease: report of a case and review of the literature. Pediatr Dev Pathol. 2016;19(2):150–3.CrossRefPubMedGoogle Scholar
  7. 7.
    Tuysuz G, Ozdemir N, Senyuz OF, Emre S, Kantarcioglu S, Adaletli I, Kepil N, Tutuncu C, Celkan T. Successful management of hepatic mucormycosis in an acute lymphoblastic leukaemia patient: a case report and review of the literature. Mycoses. 2014;57(8):513–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Bernardo RM, Gurung A, Jain D, Malinis MF. Therapeutic challenges of hepatic mucormycosis in hematologic malignancy: a case report and review of the literature. Am J Case Rep. 2016;13(17):484–9.CrossRefGoogle Scholar
  9. 9.
    Mehta C, Ali MT, Metha Y, Anand JS, George JV. A rare case of isolated hepatic mucormycosis in association with hemophagocytosis syndrome. J Acute Med. 2016;6:98–101.CrossRefGoogle Scholar
  10. 10.
    Van Sickels N, Hoffman J, Stuke L, Kempe K. Survival of a patient with trauma-induced mucormycosis using an aggressive surgical and medical approach. J Trauma. 2011;70(2):507–9.CrossRefPubMedGoogle Scholar
  11. 11.
    Oliver MR, Van Voorhis WC, Boeckh M, Mattson D, Bowden RA. Hepatic mucormycosis in a bone marrow transplant recipient who ingested naturopathic medicine. Clin Infect Dis. 1996;22(3):521–4.CrossRefPubMedGoogle Scholar
  12. 12.
    Marcó del Pont J, De Cicco L, Gallo G, Llera J, De Santibanez E, D’agostino D. Hepatic arterial thrombosis due to Mucor species in a child following orthotopic liver transplantation. Transpl Infect Dis. 2000;2(1):33–5.CrossRefPubMedGoogle Scholar
  13. 13.
    Mekeel KL, Hemming AW, Reed AI, Matsumoto T, Fujita S, Schain DC, Nelson DR, Dixon LR, Fujikawa T. Hepatic mucormycosis in a renal transplant recipient. Transplantation. 2005;79(11):1636.CrossRefPubMedGoogle Scholar
  14. 14.
    Su H, Thompson GR 3rd, Cohen SH. Hepatic mucormycosis with abscess formation. Diagn Microbiol Infect Dis. 2012;73(2):192–4.CrossRefPubMedGoogle Scholar
  15. 15.
    Al-Asiri RH, Van Dijken PJ, Mahmood MA, Al-Shahed MS, Rossi ML, Osoba AO. Isolated hepatic mucormycosis in an immunocompetent child. Am J Gastroenterol. 1996;91(3):606–7.PubMedGoogle Scholar
  16. 16.
    Erdem G, Caglar M, Ceyhan M, Akcoren Z, Kanra G. Hepatic mucormycosis in a child with fulminant hepatic failure. Turk J Pediatr. 1996;38(4):511–4.PubMedGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Departments of SurgeryUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Departments of MedicineUniversity of North Carolina School of MedicineChapel HillUSA

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