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Mycopathologia

, Volume 184, Issue 1, pp 115–119 | Cite as

Case Report: A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi in Vietnam

  • Tran-Anh LeEmail author
  • Khac-Luc Nguyen
  • My-Hang Pham
  • Thuat-Thang Vi
  • Ngoc-Anh Do
Original Paper
  • 59 Downloads

Abstract

Background

Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissues caused by different melanized fungi. The disease occurs worldwide, particularly in tropical and subtropical regions but not reported in Vietnam.

Case Summary

A 47-year-old women was admitted to hospital 103, Hanoi, Vietnam, with a 10-year lasting lesion on backside of her right shank. Diagnosis of chromoblastomycosis was made after discovery of a muriform cell in histopathological examination. A black, slow-growth fungus was isolated and identified as Fonsecaea pedrosoi after molecular analysis. After 1-month treatment with itraconazole, the lesion has significant improvement.

Conclusion

This is the first case of chromoblastomycosis caused by Fonsecaea pedrosoi reported in Vietnam.

Keywords

Case report Fonsecaea pedrosoi Chromoblastomycosis Human Vietnam Molecular analysis 

Abbreviations

CBM

Chromoblastomycosis, chromomycosis

KOH

Potassium hydroxide

DNA

Deoxyribonucleic acid

dNTP

Deoxynucleotide

PCR

Polymerase chain reaction

Notes

Acknowledgements

The authors are grateful to Mr. Robert Mayrhofer and Ms. Linh Khanh Le for revising the English text.

Authors’ Contributions

KLN and NAD conducted the study, as well as morphological and molecular analyses of the isolated strain. MHP collected clinical data. TTV made the histopathological examination. TAL designed the study and created the final draft of the manuscript. All authors read and approved the final manuscript.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no competing interests.

Availability of Data and Material

The sequence generated and analyzed during the current study is available in the GenBank under the code MF MF173064.

Consent for Publication

The authors agreed to publish this article in Mycopathologia.

Ethics Approval and Consent to Participate

Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal.

References

  1. 1.
    Martınez RL, Tovar LJM. Chromoblastomycosis. Clin Dermatol. 2007;25:188–94.CrossRefGoogle Scholar
  2. 2.
    Ghanshyam Kumar Verma SV, Singh G, Shanker V, Tegta GR, Minhas S, Sharma V, et al. A case of extensive chromoblastomycosis from North India. Braz J Microbiol. 2014;45(1):275–7.CrossRefPubMedGoogle Scholar
  3. 3.
    Attapattu M. Chromoblastomycosis—a clinical and mycological study of 71 cases from Sri Lanka. Mycopathologia. 1997;137(3):145–51.CrossRefPubMedGoogle Scholar
  4. 4.
    Sophie B, Coralie Z, Ba HM, Annie L, Dea G-H, Liliane L, et al. First case of chromoblastomycosis from Bangladesh. Med Mycol Case Rep. 2015;10:1–3.CrossRefPubMedGoogle Scholar
  5. 5.
    Kim DM, Hwang SM, Suh MK, Ha GY, Choi GS, Shin J, et al. Chromoblastomycosis caused by Fonsecaea pedrosoi. Ann Dermatol. 2011;23(3):369–74.CrossRefPubMedGoogle Scholar
  6. 6.
    Kondo M, Hiruma M, Nishioka Y, Mayuzumi N, Mochida K, Ikeda S, et al. A case of chromomycosis caused by Fonsecaea pedrosoi and a review of reported cases of dematiaceous fungal infection in Japan. Mycoses. 2005;48:221–5.CrossRefPubMedGoogle Scholar
  7. 7.
    Pho MT, Burgin S. Right buttock rash for thirty years in a patient from China. Clin Infect Dis. 2009;49(3):432–78.CrossRefPubMedGoogle Scholar
  8. 8.
    Xi L, Sun J, Lu C, Liu H, Xie Z, Fukushima K, et al. Molecular diversity of Fonsecaea (Chaetothyriales) causing chromoblastomycosis in southern China. Med Mycol. 2009;47(1):27–33.CrossRefPubMedGoogle Scholar
  9. 9.
    Yang C, Chen C, Lee Y, Yang C, Chang Y, Chung W, et al. Chromoblastomycosis in Taiwan: a report of 30 cases and a review of the literature. Med Mycol. 2017;[Epub ahead of print].Google Scholar
  10. 10.
    McDaniel P, Walsh DS. Chromoblastomycosis in Western Thailand. Am J Trop Med Hyg. 2010;83(3):448.CrossRefPubMedGoogle Scholar
  11. 11.
    Alora M, Bulmer G. Chromomycosis: report of a case successfully treated with itraconazole. Philipp J Microbiol Infect Dis. 1993;22:23–7.Google Scholar
  12. 12.
    Queiroz-Telles F, de Hoog S, Santos DWCL, Salgado CG, Vicente VA, Bonifaz A, et al. Chromoblastomycosis. Clin Microbiol Rev. 2017;30(1):233–76.CrossRefPubMedGoogle Scholar
  13. 13.
    Esterre P, Andriantsimahavandy A, Ramarcel E, Pecarrere J. Forty years of chromoblastomycosis in Madagascar: a review. Am J Trop Med Hyg. 1996;55(1):45–7.CrossRefPubMedGoogle Scholar
  14. 14.
    Silva J, de Souza W, Rozental S. Chromoblastomycosis: a retrospective study of 325 cases on Amazonic Region (Brazil). Mycopathologia. 1999;143(3):171–5.CrossRefGoogle Scholar
  15. 15.
    Queiroz-telles F, Esterre P, Perez-blanco M, Vitale RG, Salgado CG, Bonifaz A. Chromoblastomycosis: an overview of clinical manifestations, diagnosis and treatment. Med Mycol. 2009;47(Special Issue):3–15.CrossRefPubMedGoogle Scholar
  16. 16.
    White T, Bruns T, Lee S, Taylor J. Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. In: Innis MA, Gelfand DH, Sninsky JJ, White TJ, editors. Protocols and applications—a laboratory manual. 1st ed. Cambridge: Academic Press; 1990. p. 315–22.Google Scholar
  17. 17.
    Kurtzman C, Robnett C. Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5′ end of the large-subunit (26S) ribosomal DNA gene. J Clin Microbiol. 1997;35(5):1216–23.PubMedGoogle Scholar
  18. 18.
    Queiroz-telles F, Mcginnis MR, Salkin I, Graybill JR. Subcutaneous mycoses. Infect Dis Clin N Am. 2003;1(17):59–85.CrossRefGoogle Scholar
  19. 19.
    Rubin H, Bruce S, Rosen T, McBride M. Evidence for percutaneous inoculation as the mode of transmission for chromoblastomycosis. J Am Acad Dermatol. 1991;25:951–4.CrossRefPubMedGoogle Scholar
  20. 20.
    Correia RTM, Valente NYS, Criado PR, da Martins JEC. Chromoblastomycosis: study of 27 cases and review of medical literature. An Bras Dermatol. 2010;85(4):448–54.CrossRefPubMedGoogle Scholar
  21. 21.
    Ramraje SN, Gokhale J, Gupta S. Cutaneous chromoblastomycosis. J Case Rep. 2013;3(2):286–90.CrossRefGoogle Scholar
  22. 22.
    Yang Y, Li W, Huang W, Zhou Y, Fan Y. Chromoblastomycosis caused by Fonsecaea: clinicopathology, susceptibility and molecular identification of seven consecutive cases in southern China. Clin Microbiol Infect. 2013;19:1023–8.CrossRefPubMedGoogle Scholar
  23. 23.
    Shi D, Zhang W, Lu G, De Hoog GS, Liang G, Mei H, et al. Chromoblastomycosis due to Fonsecaea monophora misdiagnosed as sporotrichosis and cutaneous tuberculosis in a pulmonary tuberculosis patient. Med Mycol Case Rep [Internet]. 2016;11:57–60.  https://doi.org/10.1016/j.mmcr.2016.05.001.CrossRefGoogle Scholar
  24. 24.
    Kauffman CA, Pappas PG, Sobel JD, Dismukes WE. Essentials of clinical mycology. 2nd ed. New York: Springer; 2011.CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Tran-Anh Le
    • 1
    Email author
  • Khac-Luc Nguyen
    • 1
  • My-Hang Pham
    • 2
  • Thuat-Thang Vi
    • 3
  • Ngoc-Anh Do
    • 1
  1. 1.Department of ParasitologyVietnam Military Medical University (VMMU)HanoiVietnam
  2. 2.Department of Dermatological Disease, Hospital 103Vietnam Military Medical University (VMMU)HanoiVietnam
  3. 3.Department of Pathology, Hospital 103Vietnam Military Medical University (VMMU)HanoiVietnam

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