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Mycopathologia

, Volume 184, Issue 1, pp 147–150 | Cite as

Prognostic Potential of the Panfungal Marker (1 → 3)-β-d-Glucan in Invasive Mycoses Patients

  • P. Pini
  • C. Venturelli
  • M. Girardis
  • F. Forghieri
  • E. BlasiEmail author
Short Communication
  • 33 Downloads

Abstract

We analyze the prognostic potential of (1 → 3)-β-d-glucan (BG) levels in predicting clinical outcomes in patients with invasive fungal infections, on a population undergoing 253 episodes (177 with positive and 76 with negative outcome). Using linear regression analysis, we assessed the prognostic potential of kinetically evaluated BG levels and we found an overall sensitivity and specificity of 68 and 82%, respectively. Moreover, using an interpretative algorithm based on two distinct cutoff values, we were able to predict the outcome in 84% of the studied population with a diagnostic accuracy of 82%.

Keywords

Beta glucan Panfungal marker Invasive fungal infections Prognostic evaluation 

Notes

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

All the procedures performed in the study, involving elaboration of data obtained from biological samples, were in accordance with the ethical standards of the local institutional research committee (regularly approved protocols Nos. 53/11 and 251/17) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • P. Pini
    • 1
    • 2
  • C. Venturelli
    • 2
  • M. Girardis
    • 2
  • F. Forghieri
    • 2
  • E. Blasi
    • 1
    • 2
    Email author
  1. 1.Dipartimento di Medicina Diagnostica, Clinica e di Sanità Pubblica, Istituti BiologiciUniversità degli Studi di Modena e Reggio EmiliaModenaItaly
  2. 2.Azienda Ospedaliero Universitaria-PoliclinicoModenaItaly

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