, Volume 184, Issue 1, pp 177–180 | Cite as

Asymptomatic Histoplasma Pylephlebitis in an Orthotopic Liver Transplant Recipient: A Case Report and Literature Review

  • Pakpoom PhoompoungEmail author
  • Methee Chayakulkeeree
  • Popchai Ngamskulrungroj
  • Ananya Pongpaibul
Review Paper


Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world’s first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Histopathology of the recipient’s liver showed infiltration of fungal organisms in portal vein and hepatic granulomas. Serum H. capsulatum antibody was positive, and molecular identification from the liver revealed the DNA of H. capsulatum.


Histoplasma capsulatum Histoplasmosis Pylephlebitis Liver transplant 



We would like to thank Dr. L. Joseph Wheat from Mira Vista, Indianapolis, USA, for his kind support for H. capsulatum antigen and antibody detection. All of the authors received Chalermphrakiat Grant from the Faculty of Medicine Siriraj Hospital, Mahidol University.

Compliance with Ethical Standard

Conflict of interest

All of the authors declare that they have no competing interests.

Ethical Statement

The patient reported in this study permitted us and gave the consent to disclose the details of his case.


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Copyright information

© Springer Science+Business Media B.V., part of Springer Nature 2018

Authors and Affiliations

  • Pakpoom Phoompoung
    • 1
    Email author
  • Methee Chayakulkeeree
    • 1
  • Popchai Ngamskulrungroj
    • 2
  • Ananya Pongpaibul
    • 3
  1. 1.Division of Infectious Disease and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand
  2. 2.Department of Microbiology, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand
  3. 3.Department of Pathology, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

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