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Mycopathologia

, Volume 181, Issue 7–8, pp 539–546 | Cite as

Kerion and Tinea Corporis Caused by Rabbit-Derived Trichophyton interdigitale in Three Siblings and One Consulting Doctor Using β-Tubulin Gene to Identify the Pathogen

  • Yan-Ping Yang
  • Ping Sheng
  • Zhong Liu
  • Wen Li
  • Jie-Di Wang
  • Wen-Ming Huang
  • Yi-Ming FanEmail author
Article

Abstract

Trichophyton interdigitale is generally deemed as an anamorph of Arthroderma vanbreuseghemii based on internal transcribed spacer (ITS) sequencing, but recently their anamorph/teleomorph connection should be cautioned based on β-tubulin phylogeny. We report three siblings and one consulting doctor who developed kerion and tinea corporis after contact with domestic rabbits. Seven same strains were isolated from four patients and three regions of a sick rabbit. The ITS and D1/D2 sequences of our isolate were 99 % homologous to A. Vanbreuseghemii, while β-tubulin sequence was 100 % identical to T. interdigitale. Our isolate was identified as T. interdigitale based on maximum likelihood analysis of β-tubulin. Random amplified polymorphic DNA revealed that the band patterns of five isolated strains and another rabbit-derived strain WCH023 were identical for OPF-03 and OPF-12. Skin lesions of all patients resolved completely for 2- to 6-week therapy of oral terbinafine and topical 1 % bifonazole or 1 % terbinafine cream. This study demonstrates that T. interdigitale of rabbit origin can cause various types of human dermatophytosis by mild scratch. Terbinafine may be the first choice for dermatophytosis caused by T. interdigitale.

Keywords

Kerion Tinea corporis Trichophyton interdigitale Arthroderma vanbreuseghemii Rabbit 

Notes

Acknowledgments

We thank Prof. Ruo-Yu Li (Department of Dermatology, First Hospital of Peking University, Beijing, China) for assistance with the genetic identification.

Compliance with Ethical Standards

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  • Yan-Ping Yang
    • 1
  • Ping Sheng
    • 1
  • Zhong Liu
    • 1
  • Wen Li
    • 1
  • Jie-Di Wang
    • 1
  • Wen-Ming Huang
    • 1
  • Yi-Ming Fan
    • 1
    Email author
  1. 1.Department of DermatologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina

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