Mycopathologia

, Volume 182, Issue 3–4, pp 315–318 | Cite as

Are Cystic Fibrosis Aspergillus fumigatus Isolates Different? Intermicrobial Interactions with Pseudomonas

  • Hasan Nazik
  • Richard B. Moss
  • Vyshnavi Karna
  • Karl V. Clemons
  • Niaz Banaei
  • Kevin Cohen
  • Varun Choudhary
  • David A. Stevens
Article

Abstract

Pseudomonas aeruginosa and Aspergillus fumigatus are the leading bacterial and fungal pathogens in cystic fibrosis (CF). We have shown that Af biofilms are susceptible to Pseudomonas, particularly CF phenotypes. Those studies were performed with a reference virulent non-CF Aspergillus. Pseudomonas resident in CF airways undergo profound genetic and phenotypic adaptations to the abnormal environment. Studies have also indicated Aspergillus from CF patients have unexpected profiles of antifungal susceptibility. This would suggest that Aspergillus isolates from CF patients may be different or altered from other clinical isolates. It is important to know whether Aspergillus may also be altered, as a result of that CF environment, in susceptibility to Pseudomonas. CF Aspergillus proved not different in that susceptibility.

Keywords

Aspergillus Pseudomonas Cystic fibrosis Biofilm Intermicrobial interaction 

Notes

Acknowledgements

These studies were partially supported by a Grant from the Child Health Research Institute, Stanford Transdisciplinary Initiatives Program, CIMR No. 3777 and by a gift from John Flatley, CIMR No. 3770.

Compliance with Ethical Standards

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2016

Authors and Affiliations

  1. 1.California Institute for Medical ResearchSan JoseUSA
  2. 2.Division of Infectious Diseases and Geographic Medicine, Department of MedicineStanford University School of MedicineStanfordUSA
  3. 3.Department of MicrobiologyIstanbul UniversityIstanbulTurkey
  4. 4.Division of Pulmonology, Department of PediatricsStanford University School of MedicineStanfordUSA
  5. 5.Department of PathologyStanford University School of MedicineStanfordUSA

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