Essential Oils for Treatment for Onychomycosis: A Mini-Review
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Onychomycosis are fungal infections affecting finger and toenails mainly caused by dermatophyte fungi and some Candida species. Low cure rates and frequent recurrence, development of a fungal resistance front to various antimicrobial agents topical and systemic, and an ineffective topical treatment make onychomycosis difficult to treat. Essential oils are excellent candidates for the topical treatment for onychomycosis because the development of resistance by fungi is rare, and the presence of side effects is low. They are composed of a complex variety of compounds, mainly terpenes, with low molecular weight, which may easily penetrate into the nail plate, finding the fungi elements. The complex mixture confers a broad antifungal spectrum of action, through interaction with biological membranes, interference in radical and enzymatic reaction of fungi cells. Essential oils may become the source of new therapeutic molecules, and the use of an essential oil incorporated into a topical formulation is an interesting, safe, and effective alternative for the treatment for onychomycosis. However, studies are needed to evaluate the efficacy of essential oils in the treatment for onychomycosis in vivo. This mini-review aims to present the potential use of essential oils for the treatment for onychomycosis, focusing on the last decade.
KeywordsEssential oil Onychomycosis Antifungal Topic treatment Terpenes
Fernanda thanks to Coordenação de Aperfeiçoamento Pessoal de Ensino Superior (CAPES), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), and to Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) for her scholarship. In addition, the authors thank to Susan Reid for English support.
- 4.Hammer KA, Carson CF. Antibacterial and antifungal activities of essential oils. In: Thormar H, editor. Lipids and essential oils as antimicrobial agents. Chichester, UK: John Wiley & Sons, Ltd; 2011. p. 255–95.Google Scholar
- 6.Pinto E, Pina-Vaz C, Salgueiro L, Gonçalves MJ, Costa-de-Oliveira S, Cavaleiro C, Palmeira A, Rodrigues A, Martinez-de-Oliveira J. Antifungal activity of the essential oil of Thymus pulegioides on Candida, Aspergillus and dermatophyte species. J Med Microbiol. 2006;55:1367–73.CrossRefPubMedGoogle Scholar
- 13.Pinto E, Vale-Silva L, Cavaleiro C, Salgueiro L. Antifungal activity of the clove essential oil from Syzygium aromaticum on Candida, Aspergillus and dermatophyte species. J Appl Microbiol. 2009;58:1454–62.Google Scholar
- 23.Henri I, Bassolé N, Juliani R. Essential oils in combination and their antimicrobial properties molecules. 2012;17:3989–4006.Google Scholar
- 25.Gallucci MN, Carezzano ME, Oliva MM, Demo MS, Pizzolitto RP, Zunino MP, Zygadlo JA, Dambolena JS. In vitro activity of natural phenolic compounds against fluconazole-resistant Candida species: a quantitative structure—activity relationship analysis. J Appl Microbiol. 2014;116:795–804.CrossRefPubMedGoogle Scholar
- 30.Marzoug HNB, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, Couderc F, Abderraba M, Romdhane M. Eucalyptus (gracilis, oleosa, salubris, and salmonophloia) essential oils: their chemical composition and antioxidant and antimicrobial activities. J Med Food. 2010;13(4):1005–12.CrossRefPubMedGoogle Scholar
- 32.Elaissi A, Rouis Z, Salem NAB, Mabrouk S, Salem Y, Salah KBH, Aouni M, Farhat F, Chemli R, Harzallah-Skhiri F, Khouja ML. Chemical composition of 8 eucalyptus species’ essential oils and the evaluation of their antibacterial, antifungal and antiviral activities. BMC Complement Altern Med. 2012;12:81.PubMedCentralCrossRefPubMedGoogle Scholar
- 37.Vale-Silva L, Silva MJ, Oliveira D, Gonçalves MJ, Cavaleiro C, Salgueiro L, Pinto E. Correlation of the chemical composition of essential oils from Origanum vulgare subsp. virens with their in vitro activity against pathogenic yeasts and filamentous fungi. J Med Microbiol. 2012;61:252–60.CrossRefPubMedGoogle Scholar