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Mycopathologia

, Volume 180, Issue 3–4, pp 251–255 | Cite as

A Case of Fungus Ball-Type Pansinusitis Due to Fusarium proliferatum

  • Seyed Jamal Hashemi
  • Mojtaba Mohammadi Ardehali
  • Sassan Rezaie
  • Ensieh Zibafar
  • Mohseh Gerami Shoar
  • Ali Rezaei-Matehkolaei
  • Hassan Ehteram
  • Mohammad Javad Najafzadeh
  • Mehdi NazeriEmail author
Article

Abstract

Incidence of fungal sinusitis due to the genus Fusarium has increased during the last two decades. We report a case of fungus ball sinusitis with multiple sinuses involvement in an Iranian 21-year-old woman. The patient was diagnosed as having a fungus ball-type sinusitis in computed tomography scan. The sinus biopsy revealed fungal structures on histopathological and direct microscopic examinations and a Fusarium species arose in culture. Partial sequencing of the translation elongation factor 1-alpha identified the isolate as F. proliferatum. Removal of all lesions by endoscopic surgery resulted in a favorable outcome. To the best of our knowledge, this is the first case of F. proliferatum-associated fungus ball which involved multi-sinus and highlights the efficiency of molecular methods for discrimination of fungal agents involved.

Keywords

Fusarium proliferatum Sinusitis Fungus ball TEF-1α 

Notes

Acknowledgments

This research has been funded and supported by Tehran University of Medical sciences (TUMS), Grant No. 12985.

Conflict of interest

None.

References

  1. 1.
    Nucci M, Anaissie E. Fusarium infections in immunocompromised patients. Clin Microbiol Rev. 2007;20:695–704.PubMedCentralCrossRefPubMedGoogle Scholar
  2. 2.
    Dananché C, Cassier P, Sautour M, et al. Fungaemia caused by Fusarium proliferatum in a patient without definite immunodeficiency. Mycopathologia. 2014 [Epub ahead of print].Google Scholar
  3. 3.
    Nucci M, Anaissie EJ, Queiroz-Telles F, et al. Outcome predictors of 84 patients with hematologic malignancies and Fusarium infection. Cancer. 2003;98:315–9.CrossRefPubMedGoogle Scholar
  4. 4.
    Summerbell RC, Richardson SE, Kane J. Fusarium proliferatum as an agent of disseminated infection in an immunosuppressed patient. J Clin Microbiol. 1988;26(1):82–7.PubMedCentralPubMedGoogle Scholar
  5. 5.
    Wickern GM. Fusarium allergic fungal sinusitis. J Allergy Clin Immunol. 1993;92:624.CrossRefPubMedGoogle Scholar
  6. 6.
    Nazeri M, Mohammadi Ardehali M, Moazeni M, et al. A case of fungus ball type pansinusitis caused by Schizophyllum commune. Med Mycol Case Rep. 2012;1:115–8.PubMedCentralCrossRefPubMedGoogle Scholar
  7. 7.
    Helm TN, Longworth DL, Hall GS, Bolwell BJ, Fernandez B, Tomecki KJ. Case report and review of resolved fusariosis. J Am Acad Dermatol. 1990;23:393–8.CrossRefPubMedGoogle Scholar
  8. 8.
    Herbrecht R, Kessler R, Kravanja C, Meyer MH, Waller J, Letscher-Bru V. Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient. J Heart Lung Transplant. 2004;23:1451–4.CrossRefPubMedGoogle Scholar
  9. 9.
    Palmore TN, Shea YR, Childs RW, Sherry RM, Walsh TJ. Fusarium proliferatum soft tissue infection at the site of a puncture by a plant: recovery, isolation, and direct molecular identification. J Clin Microbiol. 2010;48:338–42.PubMedCentralCrossRefPubMedGoogle Scholar
  10. 10.
    Anaissie EJ, McGinnis MR, Pfaller MA. Clinical mycology. Philadelphia: Elsevier Science; 2009. p. 313–7.Google Scholar
  11. 11.
    Abastabar M, Mirhendi H, Rezaei-Matehkolaei A, Shidfar MR, Kordbacheh P, Makimura K. Restriction analysis of β-Tubulin genefor differentiation of the common pathogenic dermatophytes. J Clin Lab Anal. 2014;28:91–6.CrossRefPubMedGoogle Scholar
  12. 12.
    O’Donnell K, Kistler HC, Cigelnik E, Ploetz RC. Multiple evolutionary origins of the fungus causing Panama disease of banana: concordant evidence from nuclear and mitochondrial gene genealogies. Proc Natl Acad Sci USA. 1998;95:2044–9.PubMedCentralCrossRefPubMedGoogle Scholar
  13. 13.
    Clinical and Laboratory Standards Institute. Reference method for broth dilution antifungal susceptibility testing of filamentous fungi. CLSI Document M38-A2, Wayne, PA 2008.Google Scholar
  14. 14.
    Stammberger H. Endoscopic surgery for mycotic and chronic recurring sinusitis. Ann Otol Rhinol Laryngol Suppl. 1985;119:1–11.PubMedGoogle Scholar
  15. 15.
    Chakrabarti A, Das A, Panda NK. Overview of fungal rhinosinusitis. Indian J Otolaryngol Head Neck Surg. 2004;56:251–8.PubMedCentralPubMedGoogle Scholar
  16. 16.
    Kurien M, Anandi V, Raman R, Brahmadathan KN. Maxillary sinus fusariosis in immunocompetent hosts. J Laryngol Otol. 1992;106:733–6.CrossRefPubMedGoogle Scholar
  17. 17.
    Hattori N, Shirai A, Sugiura Y, et al. Onychomycosis caused by Fusarium proliferatum. Br J Dermatol. 2005;153(3):647–9.CrossRefPubMedGoogle Scholar
  18. 18.
    Ferrer C, Alio J, Rodriguez A, Andreu M, Colom F. Endophthalmitis caused by Fusarium proliferatum. J Clin Microbiol. 2005;43:5372–5.PubMedCentralCrossRefPubMedGoogle Scholar
  19. 19.
    Peterson A, Pham MH, Lee B, et al. Intracranial fusarium fungal abscess in an immunocompetent patient: case report and review of the literature. J Neurol Surg Rep. 2014;75:e241–5.PubMedCentralCrossRefPubMedGoogle Scholar
  20. 20.
    Soler ZM, Schlosser RJ. The role of fungi in diseases of the nose and sinuses. Am J Rhinol Allergy. 2012;26:351–8.PubMedCentralCrossRefPubMedGoogle Scholar
  21. 21.
    Tsai TL, Guo YC, Ho CY, Lin CZ. The role of ostiomeatal complex obstruction in maxillary fungus ball. Otolaryngol Head Neck Surg. 2006;134:494–8.CrossRefPubMedGoogle Scholar
  22. 22.
    Nomura K, Asaka D, Nakayama T, et al. Sinus Fungus Ball in the Japanese population: clinical and imaging characteristics of 104 cases. Int J Otolaryngol. 2013;2013:731640.PubMedCentralCrossRefPubMedGoogle Scholar
  23. 23.
    Liu K, Howell DN, Perfect JR, Schell WA. Morphologic criteria for the preliminary identification of Fusarium, Paecilomyces, and Acremonium species by histopathology. Am J Clin Pathol. 1998;109:45–54.PubMedGoogle Scholar
  24. 24.
    O’Donnell K, Sutton DA, Rinaldi MG, et al. Internet-accessible DNA sequence database for identifying Fusaria from human and animal infections. J Clin Microbiol. 2010;48:3708–18.PubMedCentralCrossRefPubMedGoogle Scholar
  25. 25.
    Netkovski J, Shirgoska B. Fungal rhinosinusitis. Prilozi. 2012;33:187–91.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  • Seyed Jamal Hashemi
    • 1
  • Mojtaba Mohammadi Ardehali
    • 2
  • Sassan Rezaie
    • 1
  • Ensieh Zibafar
    • 1
  • Mohseh Gerami Shoar
    • 1
  • Ali Rezaei-Matehkolaei
    • 3
    • 7
  • Hassan Ehteram
    • 4
  • Mohammad Javad Najafzadeh
    • 5
  • Mehdi Nazeri
    • 6
    Email author
  1. 1.Department of Medical Mycology & Parasitology, School of Public HealthTehran University of Medical SciencesTehranIran
  2. 2.Otorhinolaryngology Research Center, Amir Alam Educational HospitalTehran University of Medical SciencesTehranIran
  3. 3.Department of Medical Mycology, School of MedicineAhvaz Jundishapur University of Medical SciencesAhvazIran
  4. 4.Department of Pathology, School of MedicineKashan University of Medical SciencesKashanIran
  5. 5.Department of Parasitology and Mycology, Ghaem Hospital, School of MedicineMashhad University of Medical SciencesMashhadIran
  6. 6.Department of Medical Mycology & Parasitology, School of MedicineKashan University of Medical SciencesKashanIran
  7. 7.Health Research Institute, Infectious and Tropical Diseases Research CenterAhvaz Jundishapur University of Medical SciencesAhvazIran

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