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Mycopathologia

, Volume 179, Issue 3–4, pp 285–291 | Cite as

Paracoccidioidomycosis in Patients with Lymphoma and Review of Published Literature

  • Lucilene Silva Ruiz e Resende
  • Alice Gadotti Yasuda
  • Rinaldo Poncio Mendes
  • Sílvio Alencar Marques
  • Lígia Niéro-Melo
  • Júlio Defaveri
  • Maria Aparecida Custódio Domingues
Article

Abstract

This paper describes four new cases of lymphomas, two Hodgkin lymphomas and two non-Hodgkin lymphomas in patients with paracoccidioidomycosis. All had mycosis diagnosed before lymphomas with Paracoccidioides brasiliensis demonstrated in several lymph nodes, as seen in the disseminated form of the disease. When lymphoma was diagnosed, one patient was under regular paracoccidioidomycosis treatment and in clinic-serological remission for this disease, another was under regular treatment but with clinic-serological mycosis activity, one had abandoned paracoccidioidomycosis treatment 6 years earlier, and the other had not yet received any kind of antifungal drugs. Three patients received treatment for lymphomas with one remaining in remission until now, one achieving tumor remission which relapsed years later, and one having only residual lymphoma in bone marrow for a decade but clinically well. All three experienced paracoccidioidomycosis clinical remission, however, serology became negative just in one. Similar previously described cases were reviewed: five Hodgkin lymphomas, three non-Hodgkin lymphomas, and one described only as “lymphoma” without specifying type; a summary of their findings is presented. Finally, there is also a brief discussion on the possible pathophysiological mechanisms involved in the concomitance of these two disorders.

Keywords

Lymphoma Cancer Neoplasia Paracoccidioidomycosis Paracoccidioides brasiliensis 

Notes

Acknowledgments

This work was partially supported by FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), Process Number: 2012/04850-6.

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Lucilene Silva Ruiz e Resende
    • 1
  • Alice Gadotti Yasuda
    • 2
  • Rinaldo Poncio Mendes
    • 3
  • Sílvio Alencar Marques
    • 4
  • Lígia Niéro-Melo
    • 1
  • Júlio Defaveri
    • 5
  • Maria Aparecida Custódio Domingues
    • 5
  1. 1.Hematology Service of the Internal Medicine Department, Botucatu Medical SchoolSão Paulo State University - UNESPBotucatuBrazil
  2. 2.Botucatu Medical SchoolSão Paulo State University - UNESPBotucatuBrazil
  3. 3.Tropical Diseases and Image Diagnosis Department, Botucatu Medical SchoolSão Paulo State University - UNESPBotucatuBrazil
  4. 4.Dermatology and Radiotherapy Department, Botucatu Medical SchoolSão Paulo State University - UNESPBotucatuBrazil
  5. 5.Pathology Department, Botucatu Medical SchoolSão Paulo State University - UNESPBotucatuBrazil

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