, Volume 174, Issue 5–6, pp 441–450 | Cite as

Chlamydospores of Rhizopus microsporus var. rhizopodiformis in Tissue of Pulmonary Mucormycosis

  • Masatomo KimuraEmail author
  • Kazuko Nishimura
  • Eisuke Enoki
  • Takaaki Chikugo
  • Osamu Maenishi


Hyphae are usually the only fungal elements found in tissue of mucormycosis, and other fungal elements are quite rarely encountered. We found chlamydospores in bronchial lumina in autopsied tissue of pulmonary mucormycosis of a diabetic patient. Chlamydospores are thick-walled, asexually produced spores arising from the modification of a hyphal segment. This is the first histologic demonstration of chlamydospores in mucormycosis in which the causative fungus is culturally identified to species level. Rhizopus microsporus var. rhizopodiformis was isolated from the present autopsied pulmonary tissue. A literature review of human infection by this fungus found 27 cases with histopathologic evidence.


Lung Mucormycosis Chlamydospore Diabetes mellitus Rhizopus microsporus var. rhizopodiformis 



The authors gratefully acknowledge the help of Mr. Yoshitaka Horiuchi, Life Science Research Institute, Kinki University, Osaka-Sayama, Osaka, Japan, in performing scanning electron microscopy of the cultured fungus and Prof. Michiaki Masuda, Department of Microbiology, Dokkyo Medical University School of Medicine for his genetic analysis.

Conflict of interest



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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Masatomo Kimura
    • 1
    Email author
  • Kazuko Nishimura
    • 2
    • 3
  • Eisuke Enoki
    • 1
  • Takaaki Chikugo
    • 1
  • Osamu Maenishi
    • 1
  1. 1.Department of Pathology, Faculty of MedicineKinki UniversityOsaka-SayamaJapan
  2. 2.Department of Microbiology, School of MedicineDokkyo Medical UniversityMibu, TochigiJapan
  3. 3.First Laboratories Co., Ltd.KawasakiJapan

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