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Mycopathologia

, Volume 173, Issue 4, pp 229–234 | Cite as

Prevalence and Distribution Profiles of Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis Responsible for Superficial Candidiasis in a Chinese University Hospital

  • Xiaobo Feng
  • Bo Ling
  • Guimei Yang
  • Xia Yu
  • Daming Ren
  • Zhirong Yao
Article

Abstract

The Candida parapsilosis complex consists of C. parapsilosis sensu stricto, C. orthopsilosis and C. metapsilosis. Recently, many studies described the prevalence of this species complex mainly in invasive candidiasis. Additionally, data showed that these three species are different in virulence and in vitro drug susceptibility. However, to our knowledge, the prevalence and distribution of the species complex in superficial candidiasis is not very clear to date. In this study, 2,128 Candida isolates from specimens of superficial candidiasis were collected over a 1-year period. Combination of routine and molecular tools, a total of 214 samples were identified to be positive for the C. parapsilosis complex (10.1%), of which 198 (92.5%) were monofungal and 16 (7.5%) were polyfungal. Among the 198 monofungal isolates, 191 (96.5%) were identified as C. parapsilosis sensu stricto, 5 (2.5%) as C. metapsilosis, and 2 (1.0%) as C. orthopsilosis species based on the molecular method. All C. parapsilosis complex isolates from the 16 polyfungal populations were found to be C. parapsilosis sensu stricto. Further analysis showed that the distribution profiles of the C. parapsilosis complex in adult patients were different from that in pediatric patients, and the prevalence rate of it varied greatly by sites of isolation. This study provides insight into the epidemiology of the species complex in superficial candidiasis.

Keywords

Superficial candidiasis Candida parapsilosis Molecular typing 

Notes

Acknowledgments

The authors thank Professor Jozef Nosek (Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic) for reference strains.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Xiaobo Feng
    • 1
    • 2
  • Bo Ling
    • 1
  • Guimei Yang
    • 3
  • Xia Yu
    • 1
    • 2
  • Daming Ren
    • 3
  • Zhirong Yao
    • 1
    • 2
  1. 1.Medical Mycology Laboratory, Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  2. 2.Department of Dermatology, Xinhua HospitalShanghai Jiaotong University School of MedicineShanghaiChina
  3. 3.State Key Laboratory of Genetic EngineeringFudan UniversityShanghaiChina

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