Mycopathologia

, Volume 173, Issue 5–6, pp 311–319

A Decade of Experience: Cryptococcus gattii in British Columbia

  • Karen H. Bartlett
  • Po-Yan Cheng
  • Colleen Duncan
  • Eleni Galanis
  • Linda Hoang
  • Sarah Kidd
  • Min-Kuang Lee
  • Sally Lester
  • Laura MacDougall
  • Sunny Mak
  • Muhammad Morshed
  • Marsha Taylor
  • James Kronstad
Article
  • 355 Downloads

Abstract

It has been over a decade since Cryptococcus gattii was first recognized as the causative organism of an outbreak of cryptococcosis on Vancouver Island, British Columbia. A number of novel observations have been associated with the study of this emergent pathogen. A novel genotype of C. gattii, VGIIa was described as the major genotype associated with clinical disease. Minor genotypes, VGIIb and VGI, are also responsible for disease in British Columbians, in both human and animal populations. The clinical major genotype VGIIa and minor genotype VGIIb are identical to C. gattii isolated from the environment of Vancouver Island. There is more heterogeneity in VGI, and a clear association with the environment is not apparent. Between 1999 and 2010, there have been 281 cases of C. gattii cryptococcosis. Risk factors for infection are reported to be age greater than 50 years, history of smoking, corticosteroid use, HIV infection, and history of cancer or chronic lung disease. The major C. gattii genotype VGIIa is as virulent in mice as the model Cryptococcus, H99 C. neoformans, although the outbreak strain produces a less protective inflammatory response in C57BL/6 mice. The minor genotype VGIIb is significantly less virulent in mouse models. Cryptococcus gattii is found associated with native trees and soil on Vancouver Island. Transiently positive isolations have been made from air and water. An ecological niche for this organism is associated within a limited biogeoclimatic zone characterized by daily average winter temperatures above freezing.

Keywords

Cryptococcus gattii Environmental hygiene Epidemiology Pathogenic factors Genotyping VGII 

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Karen H. Bartlett
    • 1
  • Po-Yan Cheng
    • 2
    • 3
  • Colleen Duncan
    • 4
  • Eleni Galanis
    • 5
  • Linda Hoang
    • 6
  • Sarah Kidd
    • 7
  • Min-Kuang Lee
    • 6
  • Sally Lester
    • 8
  • Laura MacDougall
    • 9
  • Sunny Mak
    • 5
  • Muhammad Morshed
    • 6
  • Marsha Taylor
    • 5
  • James Kronstad
    • 2
    • 3
  1. 1.School of Population and Public HealthUniversity of British ColumbiaVancouverCanada
  2. 2.Microbiology and ImmunologyUniversity of British ColumbiaVancouverCanada
  3. 3.Michael Smith LaboratoriesUniversity of British ColumbiaVancouverCanada
  4. 4.Veterinary Diagnostic LaboratoryColorado State UniversityColoradoUSA
  5. 5.Epidemiology SectionBritish Columbia Centre for Disease ControlVancouverCanada
  6. 6.Laboratory ServicesBritish Columbia Centre for Disease ControlVancouverCanada
  7. 7.Mycology UnitWomen’s and Children’s HospitalAdelaideAustralia
  8. 8.True North Veterinary DiagnosticsLangleyCanada
  9. 9.British Columbia Centre for Disease ControlVancouverCanada
  10. 10.Microbiology and Immunology, Michael Smith LaboratoriesUniversity of British ColumbiaVancouverCanada

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