Mycopathologia

, Volume 172, Issue 4, pp 293–297 | Cite as

Photodynamic Antifungal Therapy Against Chromoblastomycosis

  • Juliana Pereira Lyon
  • Conceição de Maria Pedroso e Silva Azevedo
  • Leonardo Marmo Moreira
  • Carlos José de Lima
  • Maria Aparecida de Resende
Article

Abstract

Photodynamic therapy (PDT) is a minimally invasive approach, in which a photosensitizer compound is activated by exposure to light. The activation of the sensitizer drug results in several chemical reactions, such as the production of reactive oxygen species and other reactive molecules, which presence in the biological site leads to the damage of target cells. Although PDT has been primarily developed to combat cancerous lesions, this therapy can be employed for the treatment of several conditions, including infectious diseases. A wide range of microorganisms, including Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi, have demonstrated susceptibility to antimicrobial PDT. This treatment might consist in an alternative for the management of fungal infections. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and Aspergillus niger. Chromoblastomycosis is an infection that involves skin and subcutaneous tissues caused by the traumatic inoculation of dematiaceous fungi species, being that the most prevalent are Fonsecaea pedrosoi and Claphialophora carrionii. In the present work, the clinical applications of PDT for the treatment of chromoblastomycosis are evaluated. We have employed methylene blue as photosensitizer and a LED (Light Emitting Diode) device as light source. The results of this treatment are positive, denoting the efficacy of PDT against chromoblastomycosis. Considering that great part of the published works are focused on in vitro trials, these clinical tests can be considered a relevant source of information about antifungal PDT, since its results have demonstrated to be promising. The perspectives of this kind of treatment are analyzed in agreement with the recent literature involving antifungal PDT.

Keywords

Antifungal photodynamic therapy Chromoblastomycosis Methylene blue PDT 

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Juliana Pereira Lyon
    • 1
  • Conceição de Maria Pedroso e Silva Azevedo
    • 2
  • Leonardo Marmo Moreira
    • 3
  • Carlos José de Lima
    • 4
  • Maria Aparecida de Resende
    • 5
  1. 1.Departamento de Ciências NaturaisUniversidade Federal de São João Del Rei. Praça Dom HelvécioSão João Del ReiBrazil
  2. 2.Departamento de Medicina ICentro de Ciências da Saúde, Universidade Federal do Maranhão. Rua Barão de ItaparySão LuisBrazil
  3. 3.Universidade Federal de São João Del Rei. Praça Dom HelvécioSão João Del ReiBrazil
  4. 4.Universidade Camilo Castelo Branco, Rodovia Presidente DutraSão José dos CamposBrazil
  5. 5.Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Microbiologia. Av. Antonio CarlosBelo HorizonteBrazil

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