, Volume 169, Issue 6, pp 451–455 | Cite as

On a Fatal Case of Candida krusei Pleural Empyema in a Pregnant Woman with Spontaneous Esophagus Perforation

  • Antonio Cascio
  • Mario Barone
  • Vincenzo Micali
  • Chiara Iaria
  • Demetrio Delfino
  • Antonio David
  • Maurizio Monaco
  • Francesco Monaco



Candida empyema thoracis can be a consequence of operation, gastropleural fistula, and esophageal perforation. Case report and review of the literature. A fatal case of a 45-year-old pregnant woman with Candida krusei empyema thoracis secondary to spontaneous esophagus perforation associated with candida esophagitis is reported. The case is contextualized among similar cases found through a PubMed search.


A suspect of esophagus rupture should arise in the presence of a fungal empyema. Candida esophagitis should be always considered as a possible cause or con-cause of esophagus rupture. An empirical systemic antimycotic therapy should always be considered in an ideal multidisciplinary approach to the management of patients with esophagus rupture.


Candida Candida krusei Empyema thoracis Boerhaave’s syndrome Esophageal perforation Esophageal rupture Azole Voriconazole Echinocandin Caspofungin 


Conflict of Interest

No conflict of interest to declare.


There was no financial support for this research.

Ethical Approval

Ethical approval was not required. Informed consent from the patient’s relatives.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Antonio Cascio
    • 1
  • Mario Barone
    • 2
  • Vincenzo Micali
    • 2
  • Chiara Iaria
    • 3
  • Demetrio Delfino
    • 4
    • 5
  • Antonio David
    • 6
  • Maurizio Monaco
    • 2
  • Francesco Monaco
    • 2
  1. 1.Unità Operativa di Medicina Tropicale e Parassitologia, Dipartimento di Patologia UmanaUniversità di MessinaMessinaItaly
  2. 2.Unità Operativa di Chirurgia Toracica, Dipartimento Clinico-Sperimentale di Medicina e FarmacologiaUniversità di MessinaMessinaItaly
  3. 3.AILMI (Associazione Italiana per la Lotta contro le Malattie Infettive)Università di MessinaMessinaItaly
  4. 4.Dipartimento di Patologia e Microbiologia SperimentaleUniversità di MessinaMessinaItaly
  5. 5.Dipartimento di Malattie Infettive e TropicaliUniversità “La Sapienza”RomeItaly
  6. 6.Dipartimento di Neuroscienze, Psichiatriche e AnestesiologicheUniversità di MessinaMessinaItaly

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