Genotyping and Antifungal Drug Susceptibility of the Pathogenic Yeast Trichosporon asahii Isolated from Thai Patients
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Trichosporonosis due to Trichosporon asahii is a life-threatening infection with a very poor prognosis. We analyzed the genotype of intergenic transcribed spacer (IGS) region 1 of the rRNA gene and determined the drug susceptibility of 101 T. asahii isolates obtained from Thai patients to collect basic information on trichosporonosis in Thailand. Of the five genotypes in the IGS region identified in this study, types 1 and 3 were predominant in Thailand. The distribution in Thailand differs from that in other countries, suggesting that there is a geographic substructure among T. asahii clinical isolates. Voriconazole appeared to be the most active drug.
KeywordsTrichosporon asahii Genotype Intergenic spacer region Antifungal drug susceptibility
This study was supported in part by research grants from the Asian and African Science Platform Program of the Japan Society for the Promotion of Science, and a Health Science Research Grant for “Research on Emerging and Re-emerging Infectious Diseases” from the Ministry of Health, Labor, and Welfare of Japan (TS).
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