, 167:115 | Cite as

Clinical Characteristics and Outcomes in Patients with Pulmonary Blastomycosis

  • Doug Kralt
  • Bruce Light
  • Mary Cheang
  • Tracy MacNair
  • Lyle Wiebe
  • Bill Limerick
  • Pete Sarsfield
  • Greg Hammond
  • Kerry MacDonald
  • Elly Trepman
  • John M. EmbilEmail author



Blastomycosis is an uncommon granulomatous infection caused by the thermally dimorphic fungus Blastomyces dermatitidis. The most frequent clinical infections involve the lung, skin, and bone. Pulmonary manifestations range from asymptomatic self-limited infection to severe diffuse pneumonia causing respiratory failure.


To establish the clinical characteristics and outcomes of patients with pulmonary blastomycosis diagnosed at hospitals in Manitoba and northwestern Ontario, Canada.


A retrospective review of medical records was done for 318 patients with blastomycosis in these regions.


The majority of patients were Caucasian (198 (62.5%) patients), male (193 (61%) patients), and residents of Ontario (209 (65.7%) patients). Most patients were treated in an inpatient hospital ward (266 (84%) patients) and survived (294 (92%) patients). Pulmonary involvement, either alone or associated with other sites, was present in 296 (93%) of the 318 patients; 22 (7%) patients had no evidence of pulmonary blastomycosis. The majority of patients had localized lung disease (1–3 quadrants on chest radiograph involved; 225 (82%) patients). Of 294 (92%) patients requiring hospitalization, 266 (90%) patients received all inpatient care on a general medical ward; 28 (10%) patients received some care in the intensive care unit (ICU). Factors associated with ICU admission included diffuse pulmonary disease (four quadrants involved on chest radiograph), diabetes, and prior use of antimicrobial therapy. Twenty-four (8%) patients died, and multivariate analysis showed that older age and Aboriginal ethnicity were the significant risk factors for death from blastomycosis.


Blastomycosis is a cause of serious, potentially life-threatening pulmonary infection in this geographic region.


Blastomyces dermatitidis Fungus Infection Pulmonary Extrapulmonary 



The authors thank the following for their invaluable assistance in this project: the Medical Records Departments at the Lake of the Woods District Hospital, Kenora, Ontario; Brandon General Hospital, Brandon, Manitoba; and the following Winnipeg hospitals: Victoria General Hospital, Grace General Hospital, Seven Oaks General Hospital, Concordia General Hospital, St. Boniface General Hospital, and Health Sciences Centre. The authors acknowledge the assistance of Ms. Carolyn Garlinski (manuscript preparation) and Ms. Debbie Ormiston (data base management), and Ms. Maryanne Kennedy, Ms. Lorraine Kuzyk, and Ms. Pam Schille, (data collection). The authors thank Dr. Ethan Rubenstein, Section of Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, for manuscript review and helpful comments.

Supplementary material

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(DOC 42 kb)


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Doug Kralt
    • 1
  • Bruce Light
    • 2
  • Mary Cheang
    • 3
  • Tracy MacNair
    • 4
  • Lyle Wiebe
    • 5
  • Bill Limerick
    • 5
  • Pete Sarsfield
    • 5
  • Greg Hammond
    • 2
  • Kerry MacDonald
    • 6
  • Elly Trepman
    • 7
    • 8
  • John M. Embil
    • 2
    • 7
    • 9
    Email author
  1. 1.Faculty of MedicineUniversity of ManitobaWinnipegCanada
  2. 2.Department of Medicine, Section of Infectious DiseasesUniversity of ManitobaWinnipegCanada
  3. 3.Department of Community Health Sciences, Statistical Consulting UnitUniversity of ManitobaWinnipegCanada
  4. 4.Department of Diagnostic ImagingUniversity of ManitobaWinnipegCanada
  5. 5.Northwestern Health UnitKenoraCanada
  6. 6.Lake of the Woods District HospitalKenoraCanada
  7. 7.Department of Medical MicrobiologyUniversity of ManitobaWinnipegCanada
  8. 8.Department of Orthopaedic SurgeryGrand Itasca Clinic & HospitalGrand RapidsUSA
  9. 9.Infection Prevention and Control UnitHealth Sciences CentreWinnipegCanada

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