Mycopathologia

, Volume 160, Issue 3, pp 227–234 | Cite as

Detection of Candidadubliniensis in Venezuela

  • Claudia Hartung de  Capriles
  • Sofía Mata-Essayag
  • Celina Pérez
  • Maria Teresa Colella
  • Arantza Roselló
  • Carolina Olaizola
  • Sylvia Magaldi Teresa Abate
Article

Abstract

Over the past decades there has been a significant increase in fungal infections caused by Candida species, and continues to be common in immunocompromised individuals infected with the human immunodeficiency virus (HIV). Although Candida albicans remains the fungal species most frequently isolated as an opportunistic oral pathogen, other non-albicans are often identified in this cohort of patients, including C. dubliniensis. This yeast is closely related to and shares many phenotypic characteristics with C. albicans. Colonies of these two species appear morphologically identical when not grown on special media. The shared phenotypic characteristics of C. dubliniensis and C. albicans suggest that many C. dubliniensis isolates may have been misidentified as C. albicans in the past. The present studies aim is to recover and identify C. dubliniensis, and presumptive clinical C. albicans, from the oral cavities of HIV-seropositive individuals, comparing conventional media to obtain a simple, low-cost and reliable identification system for C. dubliniensis. A total of 16 isolates (3,98%) had been obtained from 402 HIV infected individuals with recurrent oropharyngitis and were identified as C. dubliniensis. Out of these C. dubliniensis isolates 19% were resistant, with MICs above 64 μg/ml to fluconazole. This constitutes, to the authors knowledge the first recovery of this organism in Venezuela.

Key words

C. dubliniensis phenotypic genotypic HIV Venezuela 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Claudia Hartung de  Capriles
    • 1
  • Sofía Mata-Essayag
    • 1
  • Celina Pérez
    • 1
  • Maria Teresa Colella
    • 1
  • Arantza Roselló
    • 1
  • Carolina Olaizola
    • 1
  • Sylvia Magaldi Teresa Abate
    • 2
  1. 1.Sección de Micología MédicaInstituto de Medicina Tropical, Universidad Central deVenezuela
  2. 2.Sección de Biología MolecularInstituto de Medicina Tropical, Universidad Central deVenezuela
  3. 3.Sección de Micología Médica, Instituto de Medicina TropicalCiudad Universitaria, Los ChaguaramosCaracasVenezuela

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