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Mycopathologia

, Volume 160, Issue 2, pp 97–109 | Cite as

Serodiagnosis of Mycoses Using Recombinant Antigens

  • Natalia Elguezabal
  • Fernando Lopitz-Otsoa
  • Ana Laín
  • Iñigo Fernández de  Larrinoa
  • María Dolores Moragues
  • José Pontón
Mycopathologia Review

Abstract

The early diagnosis of mycoses is important for the institution of an effective antifungal therapy. Detection of antibodies against crude antigenic extracts is one of the standard techniques for the diagnosis of most mycoses. However, while these crude antigenic extracts are relatively easy to obtain, they usually show low reproducibility and are not very specific, since antibodies from patients with different mycoses may show cross-reactivity. The application of molecular biology techniques to the study of fungal antigens has allowed the production of recombinant antigens that may help to solve these problems. The purpose of this review is to discuss the use of recombinant fungal antigens in the diagnosis of mycoses.

Keywords

diagnosis mycoses recombinant antigens 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Natalia Elguezabal
    • 1
  • Fernando Lopitz-Otsoa
    • 2
  • Ana Laín
    • 1
  • Iñigo Fernández de  Larrinoa
    • 3
  • María Dolores Moragues
    • 4
  • José Pontón
    • 1
  1. 1.Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y OdontologíaUniversidad del País VascoBilbaoSpain
  2. 2.Facultad de FarmaciaUniversidad del País VascoSpain
  3. 3.Departamento de Bioquímica, Facultad de QuímicaUniversidad del País VascoSpain
  4. 4.Departamento de Enfermería IUniversidad del País VascoSpain

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