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Mycopathologia

, Volume 161, Issue 4, pp 219–223 | Cite as

Virulence Factors and Antifungal Susceptibility of Candida albicans Isolates from Oral Candidosis Patients and Control Individuals

  • Cristiane Yumi Koga-Ito
  • Juliana Pereira Lyon
  • Valerio Vidotto
  • Maria Aparecida de Resende
Article

Abstract

Sixty isolates of Candida albicans, 30 obtained from the oral cavity of denture wearers presenting signs of candidosis and 30 obtained from the oral cavity of denture wearers with normal palatal mucosa were assayed for phospholipase and proteinase production, as well as for adherence to buccal epithelial cells. Likewise, susceptibility of the isolates to antifungals was determined by the NCCLS reference method and the E-test method. Proteinase activity was increased among the strains obtained from oral candidosis patients. In contrast, no significant differences between the two groups of isolates were observed in their adherence ability in vitro, in phospholipase production, and susceptibility to antifungal drugs.

Keywords

antifungal susceptibility adhesion Candida albicans enzyme production virulence factors 

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Copyright information

© Springer 2006

Authors and Affiliations

  • Cristiane Yumi Koga-Ito
    • 1
  • Juliana Pereira Lyon
    • 1
  • Valerio Vidotto
    • 2
  • Maria Aparecida de Resende
    • 1
  1. 1.Departamento de Microbiologia, Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Laboratorio di Micologia Medica, Sez. Malattie Infettive, Dipartimento Discipline Medico-ChirurgicheUniversitá di TorinoTurinItaly

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