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Long non-coding RNA small nucleolar RNA host genes: functions and mechanisms in hepatocellular carcinoma

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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system, with a high degree of malignancy. Although treatment methods are constantly improving, the mortality of patients is still very high, and the small nucleolar RNA host gene (SNHG) plays an important role in the occurrence and development of cancer. It can activate downstream signaling molecules by acting on microRNA and microRNA target genes, promote the proliferation, invasion, and migration of HCC cells, and provide a new molecular target for the treatment of HCC. At present, the molecular mechanisms of HCC remain unclear. In this study, the mechanism and signaling pathway of SNHG in HCC are reviewed, which provides a theoretical basis for the clinical treatment of HCC.

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Acknowledgements

We gratefully acknowledge the help and support from the general surgery clinical medicine center of Gansu Provincial Hospital, the general surgery clinical quality control center of Gansu Provincial Hospital and Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology, Gansu Provincial Hospital. In addition, we would like to thank Editage (www. editage. cn) for English language editing.

Funding

This work was supported by National Natural Science Foundation of China, No. 81660398; Hospital Key Program of National Scientific Research Cultivation Plan, No. 19SYPYA-12;Gansu Province innovation base and talent Project Funding, No. 20JR10RA433. And the fundings can support the publication of this manuscript.

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Authors and Affiliations

  1. College of Clinical Medicine, Ningxia Medical University, Yinchuan, 750000, China

    Yuan Li

  2. Department of General Surgery, Gansu Provincial Hospital, Lanzhou, 730000, China

    Yuan Li, Xinxin Wang, Shiyong Chen, Biao Wu, Yu He, Xueqin Du & Xiaojun Yang

  3. School of People’s Clinical Medicine, Lanzhou University, Lanzhou, 730000, China

    Xiaojun Yang

  4. Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology, Gansu Provincial Hospital, Lanzhou, 730000, China

    Xiaojun Yang

  5. Gansu Research Center of Prevention and Control Project for Digestive Oncology, Gansu Provincial Hospital, Lanzhou, 730000, China

    Xiaojun Yang

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Y L and XJ Y are the main contributors to the writing, production and proofreading of this paper. All authors also participated in the data access and final typesetting.

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Li, Y., Wang, X., Chen, S. et al. Long non-coding RNA small nucleolar RNA host genes: functions and mechanisms in hepatocellular carcinoma. Mol Biol Rep 49, 2455–2464 (2022). https://doi.org/10.1007/s11033-021-07018-0

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