NLRC5: new cancer buster?

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Recent decades, there is significant progress in understanding the mechanisms of tumor progression and immune evasion. The newly discovered protein NLRC5 is demonstrated to participate in regulating cancer immune escape through enhancing MHC class I genes expression in certain tumors. Nevertheless, increasing evidence has revealed that NLRC5 is up-regulated in some other tumors and promote tumor development and progression. The purpose of this review is to describe the role of NLRC5 in tumors and discuss whether NLRC5 can be a potential target in cancer treatment.

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NLR caspase recruitment domain containing protein 5


Nucleotide-binding oligomerization domain-like receptors


Caspase activation and recruitment domain


Leucine-rich repeat


Present in NAIP, CIITA, HET-E, and TP1proteins


Signal transducer and activator of transcription 1


Major histocompatibility complex


The Cancer Genome Atlas




Lung adenocarcinoma


Lung squamous cell carcinoma


Prostate adenocarcinoma


Skin cutaneous melanoma


Thyroid carcinoma




Uterine corpus endometrial carcinoma


Uterine carcinosarcoma


Esophageal carcinoma


Glioblastoma multiforme


Head and neck squamous cell carcinoma


Kidney chromophobe


Kidney renal clear cell carcinoma


Acute myeloid leukemia


Pancreatic adenocarcinoma


Stomach adenocarcinoma


Testicular germ cell tumors




Human leukocyte antigen




Antigen processing transporter


Endoplasmic reticulum


MHC class I transactivator


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I gratefully acknowledge the Second Affiliated Hospital of Anhui Medical University.


This study was funded by the National Natural Science Foundation of China (No. 81072066).

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Correspondence to Feng Tang or Bing Zhao.

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The authors declare no conflicts of interest. Feng Tang and Yadi Xu are joint first authors. Zhao Bing and Feng Tang are joint corresponding authors.

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Tang, F., Xu, Y. & Zhao, B. NLRC5: new cancer buster?. Mol Biol Rep (2020).

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  • NLRC5
  • Tumor
  • Immunotherapy