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Abnormal vitamin D and lipid profile in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients

  • Reza Derakhshan
  • Ali Mirhosseini
  • Sanaz Ahmadi Ghezeldasht
  • Hamid Reza Jahantigh
  • Mehran Mohareri
  • Reza Boostani
  • Mohammad Derakhshan
  • Seyed Abdolrahim RezaeeEmail author
Original Article

Abstract

The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease of host-HTLV-1 interactions. In many virus-associated diseases and multiple sclerosis, the importance of vitamin-D and lipid profile has been demonstrated, thus similarly, their impacts were evaluated in HAM/TSP patients, in this study. Vitamin D and lipid profile were assessed in 120 healthy subjects (HSs), along with a proviral load (PVL) in 91 HAM/TSPs and 169 HTLV-1 carriers (ACs). The mean level of triglyceride and LDL in the HAM/TSPs were higher than HSs (P = 0.008 and 0.008, respectively), but no significant difference has been found between ACs and HSs. However, the level of HDL and vitamin-D in the HAM/TSP subjects were lower than HSs (P = 0.01 and P = 0.006, respectively). In HTLV-1 infected subjects, PVL was statistically associated with cholesterol (R = 0.24, P = 0.038), triglycerides (R = 0.26, P = 0.01) and HDL (R = 0.28, P = 0.001), and in HAM/TSPs there was a strong association between the severity of the disease, as determined by the OMDS and cholesterol (P = 0.01). Furthermore, in the HAM/TSPs, positive correlations between vitamin-D and age (R = 0.23, P = 0.028) and triglycerides (R = 0.38, P = 0.001) were found, also a significant correlation between PVL and LDL (R = 0.21, P = 0.001) and a weak correlation between PVL and OMDS (R = 0.4, P = 0.07) were noted. However, there was no correlation between PVL and urinary disturbance. Furthermore, PVL range of more than 600 copies/104 lymphocytes had a strong correlation with OMDS (P = 0.05), but not with urinary disturbance. It’s more likely that HAM/TSP patients have an imbalanced lipid profile and low levels of vitamin D and may represent a potentially useful target for intervention in HTLV-1 associated diseases.

Keywords

HTLV-1 HAM/TSP Vitamin D Lipid profile Triglycerides Cholesterol LDL HDL 

Notes

Author contributions

Concept and design of study or acquisition of data or analysis and interpretation of data; SAR, MD, AM, SAG. Drafting the article or revising it critically for important intellectual content; RD, MM, HRJ, SAG. Final approval of the version to be published; RB, SAR. Willingness to assume responsibility of the study. SAR.

Funding

This study was financially supported by Vice Chancellor for Research and Technology, Mashhad University of Medical Sciences, Mashhad, Iran, under Grant [MUMS: 1395374].

Compliance with ethical standards

Conflict of interest

All the authors declared that they have no conflict of interest.

References

  1. 1.
    Lepoutre V, Jain P, Quann K, Wigdahl B, Khan ZK (2009) Role of resident CNS cell populations in HTLV-1-associated neuroinflammatory disease. Front Biosci 14:1152–1168CrossRefGoogle Scholar
  2. 2.
    Mozhgani SHR, Jaberi N, Rezaee SA, Bustani R, Jazayeri SM, Mahdi Akbarian M, Milani S, Tarokhian H, Norouzi M (2017) Evaluation of HTLV-1 HBZ and proviral load, together with host IFN λ3, in pathogenesis of HAM/TSP. J Med Virol 89(6):1102–1107CrossRefGoogle Scholar
  3. 3.
    Valenti L, Pulixi EA, Arosio P, Cremonesi L, Biasiotto G, Dongiovanni P, Maggioni M, Fargion S, Fracanzani AL (2007) Relative contribution of iron genes, dysmetabolism and hepatitis C virus (HCV) in the pathogenesis of altered iron regulation in HCV chronic hepatitis. Haematologica 92(8):1037–1042CrossRefGoogle Scholar
  4. 4.
    Friis H, Michaelsen K (1998) Micronutrients and HIV infection: a review. Eur J Clin Nutr 52(3):157–163CrossRefGoogle Scholar
  5. 5.
    Rashed MN (2011) The role of trace elements on hepatitis virus infections: a review. J Trace Elem Med Biol 25(3):181–187CrossRefGoogle Scholar
  6. 6.
    Selvaraju R, Raman RG, Narayanaswamy R, Valliappan R, Baskaran R (2009) Trace element analysis in hepatitis B affected human blood serum by inductively coupled plasma-atomic emission spectroscopy (ICP-AES). Rom J Biophys 19:35–42Google Scholar
  7. 7.
    Bikle DD (2009) Vitamin D and immune function: understanding common pathways. Curr Osteoporos Rep 7(2):58–63CrossRefGoogle Scholar
  8. 8.
    Hathcock JN, Shao A, Vieth R, Heaney R (2007) Risk assessment for vitamin D. Am J Clin Nutr 85(1):6–18CrossRefGoogle Scholar
  9. 9.
    Haahr S, Höllsberg P (2006) Multiple sclerosis is linked to Epstein-Barr virus infection. Rev Med Virol 16(5):297–310CrossRefGoogle Scholar
  10. 10.
    Holmøy T (2008) Vitamin D status modulates the immune response to Epstein Barr virus: synergistic effect of risk factors in multiple sclerosis. Med Hypotheses 70(1):66–69CrossRefGoogle Scholar
  11. 11.
    Koizumi A, Mizukami H, Inoue M (2005) pX gene causes hypercholesterolemia in hypercholesterolemia-resistant BALB/c mice. Biol Pharm Bull 28(9):1731–1735CrossRefGoogle Scholar
  12. 12.
    Gaspar G, Souza M, Masteguim T, Matta S, Casseb J, Olival G, Marcusso R, Oliveira A (2014) Medical conditions, social and neurological patients of the T-lymphotropic virus humanities-HTLV I. Retrovirology 11(1):P35CrossRefGoogle Scholar
  13. 13.
    Nakagawa M, Nakahara K, Maruyama Y, Kawabata M, Higuchi I, Kubota H, Izumo S, Arimura K, Osame M (1996) Therapeutic trials in 200 patients with HTLV-Iassociated myelopathy/tropical spastic paraparesis. J Neurovirol 2(5):345–355CrossRefGoogle Scholar
  14. 14.
    Rafatpanah H, Rezaee A, Etemadi MM, Hosseini RF, Khorram B, Afsahr L, Taylor G, Mokhber N, Mahmoudi M, Abbaszadegan MR, Foroghipor M, Hashemi P, Amiri A, Tehrani M, Azarpazhooh A, Azarpazhooh MR (2012) The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran. J Neuroimmunol 250(1–2):87–93CrossRefGoogle Scholar
  15. 15.
    Rafatpanah H, Hedayati-Moghaddam MR, Fathimoghadam F, Bidkhori HR, Shamsian SK, Ahmadi S, Sohgandi L, Azarpazhooh MR, Rezaee SA, Farid R, Bazarbachi A (2011) High prevalence of HTLV-I infection in Mashhad, Northeast Iran: a population-based seroepidemiology survey. J Clin Virol 52(3):172–176CrossRefGoogle Scholar
  16. 16.
    Grassi MF, Olavarria VN, Kruschewsky Rde A, Yamano Y, Jacobson S, Taylor GP, Martin F, Galvao-Castro B (2013) Utility of HTLV proviral load quantification in diagnosis of HTLV-1-associated myelopathy requires international standardization. J Clin Virol 58(3):584–586CrossRefGoogle Scholar
  17. 17.
    Hedayati MMR (2013) Seroepidemiology of human T-cell lymphotropic virus type 1 infection in Iran: an overviewGoogle Scholar
  18. 18.
    Andrade RG, Goncalves Pde C, Ribeiro MA, Romanelli LC, Ribas JG, Torres EB, Carneiro-Proietti AB, Barbosa-Stancioli EF, Martins ML (2013) Strong correlation between tax and HBZ mRNA expression in HAM/TSP patients: distinct markers for the neurologic disease. J Clin Virol 56(2):135–140CrossRefGoogle Scholar
  19. 19.
    Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M (2012) Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. J Surg Res 177(1):e35–e43CrossRefGoogle Scholar
  20. 20.
    Szodoray P, Nakken B, Gaal J, Jonsson R, Szegedi A, Zold E, Szegedi G, Brun J, Gesztelyi R, Zeher M (2008) The complex role of vitamin D in autoimmune diseases. Scand J Immunol 68(3):261–269CrossRefGoogle Scholar
  21. 21.
    Teymoori-Rad M, Shokri F, Salimi V, Marashi SM (2019) The interplay between vitamin D and viral infections. Rev Med Virol 29(2):e2032CrossRefGoogle Scholar
  22. 22.
    Ginde AA, Mansbach JM, Camargo CA (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 169(4):384–390CrossRefGoogle Scholar
  23. 23.
    Bergman P, Walter-Jallow L, Broliden K, Agerberth B, Soderlund J (2007) The antimicrobial peptide LL-37 inhibits HIV-1 replication. Curr HIV Res 5(4):410–415CrossRefGoogle Scholar
  24. 24.
    Howell MD, Jones JF, Kisich KO, Streib JE, Gallo RL, Leung DY (2004) Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum. J Immunol 172(3):1763–1767CrossRefGoogle Scholar
  25. 25.
    Yasin B, Pang M, Turner J, Cho Y, Dinh N, Waring A, Lehrer R, Wagar E (2000) Evaluation of the inactivation of infectious herpes simplex virus by host-defense peptides. Eur J Clin Microbiol Infect Dis 19(3):187–194CrossRefGoogle Scholar
  26. 26.
    Barlow PG, Svoboda P, Mackellar A, Nash AA, York IA, Pohl J, Davidson DJ, Donis RO (2011) Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS ONE 6(10):e25333CrossRefGoogle Scholar
  27. 27.
    Schögler A, Muster RJ, Kieninger E, Casaulta C, Tapparel C, Jung A, Moeller A, Geiser T, Regamey N, Alves MP (2016) Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37. Eur Respir J 47(2):520–530CrossRefGoogle Scholar
  28. 28.
    Gal-Tanamy M, Bachmetov L, Ravid A, Koren R, Erman A, Tur-Kaspa R, Zemel R (2011) Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes. Hepatology 54(5):1570–1579CrossRefGoogle Scholar
  29. 29.
    Liu PT, Stenger S, Tang DH, Modlin RL (2007) Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J Immunol 179(4):2060–2063CrossRefGoogle Scholar
  30. 30.
    Bahar-Shany K, Ravid A, Koren R (2010) Upregulation of MMP-9 production by TNFα in keratinocytes and its attenuation by vitamin D. J Cell Physiol 222(3):729–737PubMedGoogle Scholar
  31. 31.
    Smolders J, Thewissen M, Peelen E, Menheere P, Tervaert JWC, Damoiseaux J, Hupperts R (2009) Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS ONE 4(8):e6635CrossRefGoogle Scholar
  32. 32.
    Nunnari G, Fagone P, Lazzara F, Longo A, Cambria D, Di Stefano G, Palumbo M, Malaguarnera L, Di Rosa M (2016) Vitamin D 3 inhibits TNFα-induced latent HIV reactivation in J-LAT cells. Mol Cell Biochem 418(1–2):49–57CrossRefGoogle Scholar
  33. 33.
    Khare D, Godbole NM, Pawar SD, Mohan V, Pandey G, Gupta S, Kumar D, Dhole TN, Godbole MM (2013) Calcitriol [1, 25 [OH] 2 D3] pre-and post-treatment suppresses inflammatory response to influenza A (H1N1) infection in human lung A549 epithelial cells. Eur J Nutr 52(4):1405–1415CrossRefGoogle Scholar
  34. 34.
    Ratner L, Poiesz BJ (1988) Leukemias associated with human T-cell lymphotropic virus type I in a non-endemic region. Medicine 67(6):401CrossRefGoogle Scholar
  35. 35.
    Wielgosz MM, Rauch DA, Jones KS, Ruscetti FW, Ratner L (2005) Cholesterol dependence of HTLV-I infection. AIDS Res Hum Retrovir 21(1):43–50CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Reza Derakhshan
    • 1
  • Ali Mirhosseini
    • 1
    • 2
  • Sanaz Ahmadi Ghezeldasht
    • 1
    • 2
    • 3
  • Hamid Reza Jahantigh
    • 1
  • Mehran Mohareri
    • 1
  • Reza Boostani
    • 4
  • Mohammad Derakhshan
    • 5
  • Seyed Abdolrahim Rezaee
    • 1
    • 6
    Email author
  1. 1.Inflammation and Inflammatory Diseases Division, Immunology Research CenterMashhad University of Medical SciencesMashhadIran
  2. 2.Student Research CommitteeMashhad University of Medical SciencesMashhadIran
  3. 3.Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR)MashhadIran
  4. 4.Neurology Dept., Ghaem Hospital, Medical SchoolMashhad University of Medical SciencesMashhadIran
  5. 5.Microbiology Research Center, Buali Research InstituteMashhad University of Medical SciencesMashhadIran
  6. 6.Inflammation and Inflammatory Diseases Research Centre, Faculty of MedicineMashhad University of Medical SciencesMashhadIran

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