Abnormal vitamin D and lipid profile in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients

  • Reza Derakhshan
  • Ali Mirhosseini
  • Sanaz Ahmadi Ghezeldasht
  • Hamid Reza Jahantigh
  • Mehran Mohareri
  • Reza Boostani
  • Mohammad Derakhshan
  • Seyed Abdolrahim RezaeeEmail author
Original Article


The HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease of host-HTLV-1 interactions. In many virus-associated diseases and multiple sclerosis, the importance of vitamin-D and lipid profile has been demonstrated, thus similarly, their impacts were evaluated in HAM/TSP patients, in this study. Vitamin D and lipid profile were assessed in 120 healthy subjects (HSs), along with a proviral load (PVL) in 91 HAM/TSPs and 169 HTLV-1 carriers (ACs). The mean level of triglyceride and LDL in the HAM/TSPs were higher than HSs (P = 0.008 and 0.008, respectively), but no significant difference has been found between ACs and HSs. However, the level of HDL and vitamin-D in the HAM/TSP subjects were lower than HSs (P = 0.01 and P = 0.006, respectively). In HTLV-1 infected subjects, PVL was statistically associated with cholesterol (R = 0.24, P = 0.038), triglycerides (R = 0.26, P = 0.01) and HDL (R = 0.28, P = 0.001), and in HAM/TSPs there was a strong association between the severity of the disease, as determined by the OMDS and cholesterol (P = 0.01). Furthermore, in the HAM/TSPs, positive correlations between vitamin-D and age (R = 0.23, P = 0.028) and triglycerides (R = 0.38, P = 0.001) were found, also a significant correlation between PVL and LDL (R = 0.21, P = 0.001) and a weak correlation between PVL and OMDS (R = 0.4, P = 0.07) were noted. However, there was no correlation between PVL and urinary disturbance. Furthermore, PVL range of more than 600 copies/104 lymphocytes had a strong correlation with OMDS (P = 0.05), but not with urinary disturbance. It’s more likely that HAM/TSP patients have an imbalanced lipid profile and low levels of vitamin D and may represent a potentially useful target for intervention in HTLV-1 associated diseases.


HTLV-1 HAM/TSP Vitamin D Lipid profile Triglycerides Cholesterol LDL HDL 


Author contributions

Concept and design of study or acquisition of data or analysis and interpretation of data; SAR, MD, AM, SAG. Drafting the article or revising it critically for important intellectual content; RD, MM, HRJ, SAG. Final approval of the version to be published; RB, SAR. Willingness to assume responsibility of the study. SAR.


This study was financially supported by Vice Chancellor for Research and Technology, Mashhad University of Medical Sciences, Mashhad, Iran, under Grant [MUMS: 1395374].

Compliance with ethical standards

Conflict of interest

All the authors declared that they have no conflict of interest.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Reza Derakhshan
    • 1
  • Ali Mirhosseini
    • 1
    • 2
  • Sanaz Ahmadi Ghezeldasht
    • 1
    • 2
    • 3
  • Hamid Reza Jahantigh
    • 1
  • Mehran Mohareri
    • 1
  • Reza Boostani
    • 4
  • Mohammad Derakhshan
    • 5
  • Seyed Abdolrahim Rezaee
    • 1
    • 6
    Email author
  1. 1.Inflammation and Inflammatory Diseases Division, Immunology Research CenterMashhad University of Medical SciencesMashhadIran
  2. 2.Student Research CommitteeMashhad University of Medical SciencesMashhadIran
  3. 3.Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR)MashhadIran
  4. 4.Neurology Dept., Ghaem Hospital, Medical SchoolMashhad University of Medical SciencesMashhadIran
  5. 5.Microbiology Research Center, Buali Research InstituteMashhad University of Medical SciencesMashhadIran
  6. 6.Inflammation and Inflammatory Diseases Research Centre, Faculty of MedicineMashhad University of Medical SciencesMashhadIran

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