Molecular Biology Reports

, Volume 46, Issue 3, pp 2771–2778 | Cite as

Long non-coding RNA SNHG6 is upregulated in prostate cancer and predicts poor prognosis

  • Youji Yan
  • Zhongjun Chen
  • Yu Xiao
  • Xinghuan Wang
  • Kaiyu QianEmail author
Original Article


Certain long non-coding RNAs (lncRNAs) have been reported to be differentially expressed in various human cancer types, including prostate cancer (PCa). PCa is the most commonly diagnosed cancer type in men and lacks sensitive and accurate biomarkers. Emerging studies have indicated that certain lncRNAs are dysregulated and have crucial roles in PCa progression. The present study reported that the novel lncRNA small nucleolar RNA host gene 6 (SNHG6) is overexpressed in PCa compared with that in normal prostate tissues. In The Cancer Genome Atlas and Taylor datasets, high expression of SNHG6 in PCa tissues was identified to be significantly associated with shorter disease-free survival. In order to reveal the potential mechanisms of the role of SNHG6 in PCa, SNHG6-associated protein–protein interaction networks were constructed. Bioinformatics analysis revealed that these SNHG6-interacting genes were associated with translation, nuclear-transcribed mRNA catabolic process, ribosomal RNA processing and mRNA splicing. Although further functional validation is warranted, the present study suggests that SNHG6 is a potential novel therapeutic target and prognostic biomarker for PCa.


Prostate cancer Long non-coding RNA Small nucleolar RNA host gene 6 Protein–protein interaction network Biomarker 



This study was supported in part by Grants from the Hubei Province Health and Family Planning Scientific Research Project (Grant No. WJ2017H0002 to YX) and the Natural Science Foundation of Hubei Province (Grant No. 2014CFA006 to XW). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors disclose no potential conflicts of interest.


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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  1. 1.Department of UrologyZhongnan Hospital of Wuhan UniversityWuhanChina
  2. 2.Department of Urology, Jingzhou Central Hospital, The Second Clinical CollegeYangtze UniversityJingzhouChina
  3. 3.Department of Biological RepositoriesZhongnan Hospital of Wuhan UniversityWuhanChina
  4. 4.Human Genetics Resource Preservation Center of Hubei ProvinceWuhanChina
  5. 5.Laboratory of Precision MedicineZhongnan Hospital of Wuhan UniversityWuhanChina

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