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Molecular Biology Reports

, Volume 46, Issue 2, pp 2567–2575 | Cite as

Functions of RNA N6-methyladenosine modification in cancer progression

  • Bing Chen
  • Ya Li
  • Ruifeng Song
  • Chen Xue
  • Feng XuEmail author
Review
  • 179 Downloads

Abstract

N6-methyladenosine (m6A) serves as a major RNA methylation modification and impacts the initiation and progression of various human cancers through diverse mechanisms. It has been reported that m6A RNA methylation is involved in different physiological and pathological processes, including stem cell differentiation and motility, immune response, cellular stress, tissue renewal and viral infection. In this review, the m6A modification and its regulatory functions in a few major cancers is introduced. The detection approaches for the m6A sites identification are discussed. Additionally, the potential of the RNA m6A modification in clinical application is discussed.

Keywords

RNA N6-methyladenosine modification Cancer progression Physiological and pathological processes Detection approaches Clinical application 

Notes

Acknowledgements

We thank the PubMed database and its contributors for this valuable public data set. We also thank Dr Menglong Zhao from Dutch Institute for Fundamental Energy Research for helping to edit this manuscript.

Author contributions

All authors participated in the preparation of the manuscript, read and approved the final manuscript.

Funding

This work was supported by the Key Project of Scientific Research Foundation for Colleges and Universities in Henan Province (Grant No. 16A320081) and National Natural Science Foundation of China (Grant No. 81802325).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Bing Chen
    • 1
  • Ya Li
    • 1
  • Ruifeng Song
    • 1
  • Chen Xue
    • 2
  • Feng Xu
    • 1
    Email author
  1. 1.Department of GastroenterologyThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China
  2. 2.Department of Infectious DiseasesThe First Affiliated Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China

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