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KIR gene presence/absence polymorphisms and global diversity in the Kirgiz ethnic minority and populations distributed worldwide

  • Hong-Dan Wang
  • Xiao-Ye Jin
  • Yu-Xin Guo
  • Qian Zhang
  • Yu-Wei Zhang
  • Xin Wang
  • Bo-Feng Zhu
Original Article

Abstract

Killer cell immunoglobulin like receptor genes expressed by the natural killer cells and T cells of some subclasses are one of the very diversity and complex gene families on chromosome 19q13.4 which play key developmental role in the fight against viral infections, malignantly transformed cells and so on in the first line. As potential markers, KIRs have received more and more attention for some infections and diseases which have some clinical outcomes. In addition, the KIRs are diverse in different populations due to the distinctive alleles and haplotypes, may contribute to understand the genetic relationships among populations. To data, there is no report on the KIR gene polymorphism of the Kirgiz ethnic minority. The purpose of this paper is to determine the KIR gene diversity: KIR gene presence/absence polymorphisms, haplotype/genotype polymorphisms and these polymorphisms between populations distributed worldwide. In this study, we have genotyped the 19 KIR genes: KIR2DL1-4, 2DL5A, 2DL5B, 2DS1-3, 2DS4*FUL, 2DS4*DEL, 2DS5, 3DL1-3, 3DS1, 2DP1, 3DP1*FUL and 3DP1*DEL, and two unique genotypes are found in two Kirgiz individuals. The PCA plot, Neighbor-Joining tree analysis and MDS plot are conducted and the groups of the same language family gather together basically. KIR gene diversity study of populations distributed in different parts of the world. shows that KIRs can be used as a supplement for human genetic researches.

Keywords

Killer cell immunoglobulin-like receptors (KIRs) Genetic diversity PCR-SSP Kirgiz ethnic minority 

Notes

Acknowledgements

The present study was supported by the National Natural Science Foundation of China (Grant Nos. 81501336 and 81525015) and the Science and Technology Research Project of Henan Province (Grant No. 172102310295).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Nature B.V. 2019

Authors and Affiliations

  • Hong-Dan Wang
    • 1
    • 2
  • Xiao-Ye Jin
    • 1
  • Yu-Xin Guo
    • 1
  • Qian Zhang
    • 2
  • Yu-Wei Zhang
    • 2
  • Xin Wang
    • 2
  • Bo-Feng Zhu
    • 1
  1. 1.Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of StomatologyXi’an Jiaotong UniversityXi’anPeople’s Republic of China
  2. 2.Medical Genetic Institute of Henan Province, Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouPeople’s Republic of China

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