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Molecular Biology Reports

, Volume 46, Issue 1, pp 991–995 | Cite as

Evaluation of the potential clinical prognostic value of lncRNA-BANCR gene in esophageal squamous cell carcinoma

  • Shiva Sadeghpour
  • Saeid GhorbianEmail author
Original Article

Abstract

Esophageal squamous cell carcinoma (ESCC) is the seventh most common cause of cancer death in worldwide. LncRNA-BANCR is a long non-coding RNA (lncRNA), which has made new windows in cancer investigations. The aim of this survey was to determine the lncRNA-BANCR gene expression changes in patients with ESCC. In case-control investigation was performed on 150 formalin fixed-paraffin embedded tissues (75 cancerous and 75 non-cancerous tissues) of ESCC patients. The lncRNA-BANCR gene expression alteration was assessed by Real-Time PCR technique. Our findings revealed that lncRNA-BANCR gene expression was increased significantly in tumor tissues compared with the non-cancerous tissues (p = 0.0025). In addition, lncRNA-BANCR gene expression changes was positively associated with the lymph node metastasis (p = 0.013), tumor differentiation (p = 0.019) and tumor stage (p = 0.017). Our results suggest a possible role of lncRNA-BANCR in proliferation of esophageal tissues and may be considered as a potential prognostic value for ESCC metastasis.

Keywords

LncRNA-BANCR gene Squamous cell carcinoma Non-coding RNA ESCC 

Notes

Acknowledgements

The present study is the result of a master’s degree dissertation, which was approved at the Ahar Branch, Islamic Azad University, Iran. The authors would like to thank all of the people who collaborated in this study.

Funding

This study has no any funded.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interests.

Research involving human participants or animals

This article does not describe any studies on human participants or animals performed by any of the authors.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Molecular Genetics, Ahar BranchIslamic Azad UniversityAharIran

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