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Mesenchymal stem cell dysfunction in diabetes

  • Arman Fijany
  • Lohrasb R. Sayadi
  • Nima Khoshab
  • Derek A. Banyard
  • Ashkaun Shaterian
  • Michael Alexander
  • Johnathan R. T. Lakey
  • Keyianoosh Z. Paydar
  • Gregory R. D. Evans
  • Alan D. Widgerow
Review

Abstract

Diabetes mellitus (DM) is a chronic disease that results in a variety of systemic complications. Recently, stem cell-based therapies have been proposed as potential modalities to manage DM related complications. Mesenchymal stem cell (MSC) based therapies are often considered as an ideal stem cell-based treatment for DM management due to their immunosuppressive characteristics, anti-inflammatory properties and differentiation potential. While MSCs show tremendous promise, the underlying functional deficits of MSCs in DM patients is not well understood. Using the MEDLINE database to define these functional deficits, our search yielded 1826 articles of which 33 met our inclusion criteria. This allowed us to review the topic and illuminate four major molecular categories by which MSCs are compromised in both Type 1 DM and Type II DM models which include: (1) changes in angiogenesis/vasculogenesis, (2) altered pro-inflammatory cytokine secretion, (3) increased oxidative stress markers and (4) impaired cellular differentiation and decreased proliferation. Knowledge of the deficits in MSC function will allow us to more clearly assess the efficacy of potential biologic therapies for reversing these dysfunctions when treating the complications of diabetic disease.

Keywords

Diabetes Mesenchymal stem cell MSC Dysfunction 

Notes

Compliance with ethical standards

Conflict of interest

The authors whose names are listed immediately above certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Arman Fijany
    • 1
  • Lohrasb R. Sayadi
    • 1
  • Nima Khoshab
    • 1
  • Derek A. Banyard
    • 1
  • Ashkaun Shaterian
    • 1
  • Michael Alexander
    • 2
  • Johnathan R. T. Lakey
    • 2
  • Keyianoosh Z. Paydar
    • 1
  • Gregory R. D. Evans
    • 1
    • 2
  • Alan D. Widgerow
    • 1
    • 2
    • 3
  1. 1.UC Irvine Department of Plastic SurgeryCenter for Tissue EngineeringOrangeUSA
  2. 2.UC Irvine Department of Surgery & Biomedical EngineeringOrangeUSA
  3. 3.University of CaliforniaOrangeUSA

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