Acute responses of hemodynamic and oxidative stress parameters to aerobic exercise with blood flow restriction in hypertensive elderly women
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Systemic arterial hypertension has been associated with the majority deaths from cardiovascular disease, especially among the elderly population, and the imbalance between antioxidant and pro-oxidants has been associated with hypertension. This study analyzed the acute responses of cardiorespiratory and oxidative stress parameters to low intensity aerobic exercise (LIAE) with blood flow restriction (BFR) in hypertensive elderly women. The experimental group consisted of 16 hypertensive women (67.2 ± 3.7 years) who underwent a progressive treadmill test and performed three exercise protocols in random order: high intensity (HIAE), low intensity aerobic exercise (LIAE) and low intensity aerobic exercise with blood flow restriction (LIAE + BFR). Data analysis showed that blood pressure and heart rate augmented from rest to post effort (p < 0.05) and reduced from post effort to recovery (p < 0.05) in all protocols. The values of lipid peroxidation were higher after 30 min of recovery when compared to the moment at rest in the LILIAE + BFR (p < 0.05). The same occurred with glutathione-S-transferase and superoxide dismutase activity. However, non-protein thiols levels (NPSH) reduced after 30 min of recovery when compared to the moment at rest in the LILIAE + BFR protocol (p < 0.05). In the HIAE and LIAE + BFR protocols, the levels of NPSH were lower at 30 min of recovery when compared to the same moment in the LIAE protocol (p < 0.05). LIAE + RBF produces an oxidative status and hemodynamic stimulus similar to HIAE. Taken together, these results support the indication of LIAE with BFR in chronic intervention protocols, with potential benefits for the hypertensive elderly population.
KeywordsExercise therapy Hypertension Antioxidant Free radicals Elderly
We thank Unochapecó University for his financial support.
Compliance with ethical standards
Conflict of interest
It is an academic work and there is no conflict of interest.
- 1.World Health Organization (2013) A global brief on hypertension: silent killer, global public health crisis. World Health Day 2013. World Health Organization, GenevaGoogle Scholar
- 3.Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine. Oxford University press, New YorkGoogle Scholar
- 8.Schulz KF, Altman DG, Moher D (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. Ann Int Med 152:726–732. https://doi.org/10.7326/0003-4819-152-11-201006010-00232 CrossRefPubMedGoogle Scholar
- 14.Warholm M, Guthenberg C, von Bahr C, Mannervik B (1985) Glutathione transferases from human liver. Methods Enzymol 113:499–504Google Scholar
- 16.Metcalf JA, Gallin JI, Nauseef WM, Root RK (1986) Laboratory manual of neutrophil function. Raven Press, New YorkGoogle Scholar
- 18.Iida H, Kurano H, Takano H, Kubota N, Morita T, Meguro K, Sato Y, Abe T, Yamazaki Y, Uno K, Takenaka K, Hirose K, Nakajima T (2007) Hemodynamic and neurohumoral responses to the restriction of femoral blood flow by KAATSU in healthy subjects. Eur J Appl Physiol 100:275–285. https://doi.org/10.1007/s00421-007-0430-y CrossRefPubMedGoogle Scholar
- 19.Ferreira MLV, Sardeli AV, Souza GV, Bonganha V, Santos LDC, Castro A, Cavaglieri CR, Chacon-Mikahil MPT (2017) Cardiac autonomic and haemodynamic recovery after a single session of aerobic exercise with and without blood flow restriction in older adults. J Sports Sci 35:2412–2420. https://doi.org/10.1080/02640414.2016.1271139 CrossRefPubMedGoogle Scholar
- 22.Ciolac EG, Guimarães GV, D’Avila VM, Bortolotto LA, Doria EL, Bocchi EA (2009) Acute effects of continuous and interval aerobic exercise on 24-h ambulatory blood pressure in long-term treated hypertensive patients. Int J Cardiol 133:381–387. https://doi.org/10.1016/j.ijcard.2008.02.005 CrossRefPubMedGoogle Scholar
- 23.Moraes MR, Bacurau RF, Ramalho JD, Reis FC, Casarini DE, Chagas JR, Oliveira V, Higa EM, Abdalla DS, Pesquero JL, Pesquero JB, Araujo RC (2007) Increase in kinins on post-exercise hypotension in normotensive and hypertensive volunteers. Biol Chem 388:533–540. https://doi.org/10.1515/BC.2007.055 CrossRefPubMedGoogle Scholar
- 37.Michailidis Y, Jamurtas AZ, Nikolaidis MG, Fatouros IG, Koutedakis Y, Papassotiriou I, Kouretas D (2007) Sampling time is crucial for measurement of aerobic exercise-induced oxidative stress. Med Sci Sports Exerc 39:1107–1113. https://doi.org/10.1249/01.mss.0b013e318053e7ba CrossRefPubMedGoogle Scholar
- 38.Powers SK, Lennon SL (1999) Analysis of cellular responses to free radicals: focus on exercise and skeletal muscle. Proc Nutr Soc 58:1025–1033Google Scholar